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一种通过光聚合实现壳聚糖纳米粒聚乙二醇化的新方法。

A novel method for PEGylation of chitosan nanoparticles through photopolymerization.

作者信息

Bozuyuk Ugur, Gokulu Ipek S, Dogan Nihal Olcay, Kizilel Seda

机构信息

Chemical and Biological Engineering, Koç University Sariyer Istanbul 34450 Turkey

出版信息

RSC Adv. 2019 May 7;9(25):14011-14015. doi: 10.1039/c9ra00780f.

DOI:10.1039/c9ra00780f
PMID:35519348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9063996/
Abstract

An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability.

摘要

通过聚乙二醇（PEG）的丙烯酸酯基团与甲基丙烯酸化壳聚糖纳米颗粒之间的光聚合反应，建立了一种超快速且便捷的壳聚糖纳米颗粒聚乙二醇化方法。通过改变PEG链长、浓度和紫外线照射时间，优化了生理pH条件下纳米颗粒的特性。本文开发的方法具有壳聚糖纳米颗粒临床转化的潜力。它还能够可扩展且快速地合成具有胶体稳定性的纳米颗粒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bb4/9063996/668eb0ea1fe5/c9ra00780f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bb4/9063996/085e6e343da9/c9ra00780f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bb4/9063996/668eb0ea1fe5/c9ra00780f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bb4/9063996/085e6e343da9/c9ra00780f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bb4/9063996/668eb0ea1fe5/c9ra00780f-f2.jpg

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ACS Appl Mater Interfaces. 2018 Oct 10;10(40):33945-33955. doi: 10.1021/acsami.8b11178. Epub 2018 Sep 26.
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Light-Triggered Drug Release from 3D-Printed Magnetic Chitosan Microswimmers.光触发的 3D 打印磁性壳聚糖微游动体药物释放。
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An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery.
壳聚糖纳米颗粒概述及其在非肠道给药中的应用
Pharmaceutics. 2017 Nov 20;9(4):53. doi: 10.3390/pharmaceutics9040053.
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Engineered nanoparticles for drug delivery in cancer therapy.用于癌症治疗中药物递送的工程纳米颗粒。
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Biocompatibility of chitosan carriers with application in drug delivery.壳聚糖载体在药物递送中的生物相容性。
J Funct Biomater. 2012 Sep 17;3(3):615-41. doi: 10.3390/jfb3030615.
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Scalable ionic gelation synthesis of chitosan nanoparticles for drug delivery in static mixers.在静态混合器中通过可扩展的离子凝胶化合成壳聚糖纳米粒子用于药物输送。
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