Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore 627833, Singapore.
Carbohydr Polym. 2013 May 15;94(2):940-5. doi: 10.1016/j.carbpol.2013.02.013. Epub 2013 Feb 18.
The purpose of this study is to synthesize chitosan (CS) nanoparticles (NPs) by ionic gelation with tripolyphosphate (TPP) as crossslinker in static mixers. The proposed static mixing technique showed good control over the ionic gelation process and 152-376 nm CS NPs were achieved in a continuous and scalable mode. Increasing the flow rates of CS:TPP solution streams, decreasing the CS concentration or reducing the CS:TPP solution volume ratio led to the smaller particles. Sylicylic acid (SA) was used as a model drug and successfully loaded into the CS NPs during the fabrication process. Our work demonstrates that ionic gelation-static mixing is a robust platform for continuous and large scale production of CS NPs for drug delivery.
本研究旨在通过离子凝胶法，以三聚磷酸钠（TPP）作为交联剂，在静态混合器中合成壳聚糖（CS）纳米颗粒（NPs）。所提出的静态混合技术对离子凝胶过程具有良好的控制作用，以连续和可扩展的方式实现了 152-376nm 的 CS NPs。增加 CS:TPP 溶液流的流速、降低 CS 浓度或减小 CS:TPP 溶液体积比都会导致颗粒变小。水杨酸（SA）被用作模型药物，并在制备过程中成功负载到 CS NPs 中。我们的工作表明，离子凝胶-静态混合是用于药物输送的 CS NPs 连续大规模生产的强大平台。
