Efficient production of coenzyme Q from acid hydrolysate of sweet sorghum juice by .

In order to achieve efficient bioconversion of biomass-derived sugars, acid hydrolysate of sweet sorghum juice (SSJAH) containing abundant fermentable sugars was used for coenzyme Q (CoQ) fermentation by CQ-09-1. The synthesis of CoQ was facilitated when the initial concentration of total sugar was 80.00 g L. And the highest CoQ titer was obtained when the pH and temperature were maintained at 7.00 and 30.00 °C, respectively. Moreover, corn steep powder (CSP) was proved to be an efficient nitrogen & salt supplement to SSJAH. Under the optimized conditions, the titer of CoQ reached 141.95 mg L in a fed-batch fermentation. The CoQ titer reported was about two times higher than that obtained in the previous study using wild strains. This process introduces a potential way to produce CoQ using the concept of biorefinery, while making full use of sweet sorghum juice (SSJ).