Ma Weimin, Huang Jiawei, Li Chao, Jiang Yueren, Li Baolin, Qi Ting, Zhu Xiaozhang
School of Chemical Sciences, University of Chinese Academy of Sciences Beijing 100049 P. R. China
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 P. R. China
RSC Adv. 2019 Mar 1;9(13):7123-7127. doi: 10.1039/c9ra00796b.
Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh) and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, KPO·3HO as the base and -butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates.
基于区域选择性分子间铃木偶联反应及随后的分子内乌尔曼碳-氧偶联反应，在对包括催化剂、溶剂、碱、配体和反应时间等反应条件进行优化后，开发了一锅法合成苯并[4,5]噻吩并[3,2-b]苯并呋喃（BTBFs）的方法。该一锅法反应仅使用2 mol%的Pd(PPh)和2 mol%的噻吩-2-羧酸铜（CuTc）作为催化剂，K₃PO₄·3H₂O作为碱，叔丁醇作为溶剂，对于多种底物可获得中等至良好的产率（高达70%）。
