Agasti Soumitra, Dey Aniruddha, Maiti Debabrata
Department of Chemistry, Indian Institute of Technology Bombay, India.
Chem Commun (Camb). 2017 Jun 16;53(49):6544-6556. doi: 10.1039/c7cc02053h.
Heterocyclic compounds are commonly found in the core structures of several pharmaceuticals, natural products, and agrochemicals, thus spurring intensive research for conducting their synthesis in a mild and simpler way. Over the years, a host of different strategies has been introduced in an effort to synthesize these heterocyles. In this context, significant attention has been gained by methodologies that ensure both step as well as atom efficiency. Synthesis of heterocyclic moieties via multiple C-H activations was found to fulfill these expectations besides guaranteeing the use of starting materials that are easily procurable. This review is focused on the current development in the field of benzofuran and indole synthesis using multiple C-H functionalization strategies.
杂环化合物常见于多种药物、天然产物和农用化学品的核心结构中，因此激发了人们对以温和、简便方式进行其合成的深入研究。多年来，为了合成这些杂环化合物，人们引入了许多不同的策略。在此背景下，确保步骤和原子效率的方法受到了广泛关注。通过多次C-H活化合成杂环部分，除了保证使用易于获得的起始原料外，还满足了这些期望。本综述聚焦于使用多种C-H官能化策略在苯并呋喃和吲哚合成领域的当前发展。
