El-Zahry Marwa R, Ali Marwa F B
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Assiut University Assiut 71526 Egypt
RSC Adv. 2019 Mar 1;9(13):7136-7146. doi: 10.1039/c8ra10415h.
The enhancement effect of reduced graphene oxide (rGO) combined with silver nanocomposite supported on poly brilliant blue (PBB) platform was investigated for ultra-trace analysis of rosuvastatin (RS). Herein, electrochemical deposition of the silver nanoparticles (AgNPs) and rGO hybrid was performed on the surface of the polymerized brilliant blue (PBB) platform. The developed (AgNPs-rGO/PBB) electrode showed an enhanced catalytic activity toward the oxidation of RS. The modified electrodes AgNPs-rGO/PBB and AgNPs/PBB required an overpotential of 0.68 and 1.06 V to achieve a current density of 10 mA cm, and their corresponding Tafel slopes were calculated to be 70 and 105 mV dec, respectively. Further, rGO and silver nanocomposites properties were characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV), square wave voltammetry (SWV), linear sweep voltammetry (LSV), and electrochemical impedance spectroscopy (EIS). Additionally, the formation of GO and AgNPs-rGO was confirmed by Raman spectroscopy and Fourier transform infrared spectroscopy (FT-IR). Under the optimized conditions, the electrochemical sensor showed a remarkable response for quantitation of RS over a wide range of concentrations 5 × 10 to 5 × 10 mol L ( = 0.9988), with a limit of detection 2.17 × 10 mol L. The electrochemical performance of the studied electrode showed high reproducibility and suitability for tablets and human plasma.
研究了负载在聚亮蓝（PBB）平台上的还原氧化石墨烯（rGO）与银纳米复合材料相结合对瑞舒伐他汀（RS）进行超痕量分析的增强效果。在此，在聚合亮蓝（PBB）平台表面进行了银纳米颗粒（AgNPs）与rGO杂化物的电化学沉积。所制备的（AgNPs-rGO/PBB）电极对RS的氧化表现出增强的催化活性。修饰电极AgNPs-rGO/PBB和AgNPs/PBB达到10 mA cm电流密度所需的过电位分别为0.68和1.06 V，其相应的塔菲尔斜率经计算分别为70和105 mV dec。此外，通过扫描电子显微镜（SEM）、循环伏安法（CV）、方波伏安法（SWV）、线性扫描伏安法（LSV）和电化学阻抗谱（EIS）对rGO和银纳米复合材料的性能进行了表征。另外，通过拉曼光谱和傅里叶变换红外光谱（FT-IR）证实了氧化石墨烯（GO）和AgNPs-rGO的形成。在优化条件下，该电化学传感器在5×10至5×10 mol L的宽浓度范围内对RS定量表现出显著响应（ = 0.9988），检测限为2.17×10 mol L。所研究电极的电化学性能显示出高重现性，适用于片剂和人体血浆检测。
