Morisaku Misaki, Ito Kaori, Ogiso Anna, Imai Misa, Hiraoka Yoshiko, Zennami Miho, Tsuge Masahiro, Mori Maiko, Toyosato Seira, Matsuda Hidezo, Ando Yosuke, Tokuda Masutaka, Tomita Akihiro, Yamada Shigeki
Department of Clinical Pharmacy, Fujita Health University, School of Medicine, Toyoake, Aichi Japan.
Department of Pharmacy, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Fujita Med J. 2022 May;8(2):59-64. doi: 10.20407/fmj.2021-006. Epub 2021 Aug 20.
Zinc (Zn) is a cofactor for more than 200 enzymes within the human body. Zn deficiency can result in cell-mediated immune dysfunction. Furthermore, serum Zn levels have been reported to be associated with nutritional status, but this association has not been clarified in malignant lymphoma. This study aimed to examine the deficiency of serum Zn levels and clarify the factors that are correlated with serum Zn in malignant lymphoma.
Initial malignant lymphoma was diagnosed in patients at Fujita Health University Hospital between April 2011 and March 2019. Based on the serum Zn levels, the study population was divided into "deficient" and "low or normal". For the serum Zn levels of patients undergoing pre-chemotherapy, laboratory parameters and nutritional factors were included. We compared these factors between the abovementioned two groups, and the serum Zn levels with its correlation factors were investigated.
A total of 77 patients (Deficient group, n=20 and Low or Normal group, n=57) were enrolled. Histology, hemoglobin, serum albumin levels, Glasgow Prognostic Score (GPS), neutrophile-lymphocyte ratio (NLR), prognostic nutrition index (PNI) and Controlling Nutritional Status (CONUT) were significantly different between the two groups. Of these parameters, only serum albumin level was significantly associated with serum Zn level (p=0.0024; estimated regression coefficient, 9.51; adjusted coefficient of determination, 0.28).
Poor nutritional status at the initial diagnosis may have affected Zn deficiency in initial malignant lymphoma.
锌（Zn）是人体内200多种酶的辅助因子。锌缺乏可导致细胞介导的免疫功能障碍。此外，据报道血清锌水平与营养状况有关，但这种关联在恶性淋巴瘤中尚未明确。本研究旨在检测恶性淋巴瘤患者血清锌水平缺乏情况，并阐明与血清锌相关的因素。
2011年4月至2019年3月期间，在藤田保健大学医院确诊为原发性恶性淋巴瘤的患者纳入研究。根据血清锌水平，将研究人群分为“缺乏组”和“低水平或正常组”。对于化疗前患者的血清锌水平，纳入实验室参数和营养因素。我们比较了上述两组之间的这些因素，并研究了血清锌水平与其相关因素。
共纳入77例患者（缺乏组，n = 20；低水平或正常组，n = 57）。两组之间的组织学、血红蛋白、血清白蛋白水平、格拉斯哥预后评分（GPS）、中性粒细胞与淋巴细胞比值（NLR）、预后营养指数（PNI）和控制营养状况（CONUT）存在显著差异。在这些参数中，只有血清白蛋白水平与血清锌水平显著相关（p = 0.0024；估计回归系数，9.51；调整后的决定系数，0.28）。
初诊时营养状况较差可能影响原发性恶性淋巴瘤患者的锌缺乏情况。
