Li Ruiyan, Wei Yongjie, Gu Long, Qin Yanguo, Li Dongdong
Department of Orthopedics, The Second Hospital of Jilin University Changchun 130041 China
Key Laboratory of Automobile Materials of MOE, Department of Materials Science and Engineering, Jilin University Changchun 130012 China
RSC Adv. 2020 May 27;10(34):20020-20027. doi: 10.1039/d0ra01079k. eCollection 2020 May 26.
Tantalum (Ta) is an element with high chemical stability and ductility that is used in orthopedic biomaterials. When utilized, it can produce a bioactive surface and enhance cell-material interactions, but currently, there exist scarce effective methods to introduce the Ta element onto the surface of implants. This work reported a sol-gel-assisted approach combined with micro-arc oxidation (MAO) to introduce Ta onto the surface of the titanium (TC4) substrate. Specifically, this technique produced a substrate with a hierarchically rough structured topography and introduced strontium ions into the film. The films were uniform and continuous with numerous crater-like micropores. Compared with the TC4 sample (196 ± 35 nm), the roughness of Ta (734 ± 51 nm) and Ta-Sr (728 ± 85 nm) films was significantly higher, and both films (Ta and Ta-Sr) showed increased hydrophilicity when compared with TC4, promoting cell attachment. Additionally, the experiments indicated that Ta and Ta-Sr films have the potential to enhance the recruitment of cells in the initial culture stages, and improve cell proliferation. Overall, this work demonstrated that the application of Ta and Ta-Sr films to orthopedic implants has the potential to increase the lifetime of the implants. Furthermore, this study also describes an innovative strategy to incorporate Ta into implant films.
钽（Ta）是一种具有高化学稳定性和延展性的元素，用于骨科生物材料。在使用时，它可以产生生物活性表面并增强细胞与材料的相互作用，但目前，将钽元素引入植入物表面的有效方法很少。这项工作报道了一种溶胶 - 凝胶辅助方法与微弧氧化（MAO）相结合，将钽引入钛（TC4）基体表面。具体而言，该技术制备出具有分级粗糙结构形貌的基体，并将锶离子引入薄膜中。薄膜均匀且连续，有许多火山口状微孔。与TC4样品（196±35纳米）相比，钽（734±51纳米）和钽 - 锶（728±85纳米）薄膜的粗糙度显著更高，并且与TC4相比，两种薄膜（钽和钽 - 锶）均表现出亲水性增加，促进细胞附着。此外，实验表明钽和钽 - 锶薄膜在初始培养阶段有增强细胞募集的潜力，并能改善细胞增殖。总体而言，这项工作表明将钽和钽 - 锶薄膜应用于骨科植入物有可能延长植入物的使用寿命。此外，本研究还描述了一种将钽掺入植入物薄膜的创新策略。
