Department of Periodontology, School of Dentistry, Kyungpook National University, Jung-Gu, Daegu, Korea.
Clin Oral Implants Res. 2013 Jun;24(6):706-9. doi: 10.1111/j.1600-0501.2012.02444.x. Epub 2012 Mar 12.
It is unclear whether surface bioactive chemistry or hydrophilicity plays a more dominant role in the osseointegration of micro-structured titanium implants having the same surface topography at the micrometer and submicrometer scales. To understand their comparative effect on enhancing the early osseointegration of micro-rough-surfaced implants, this study compared the bone healing-promoting effect of surface strontium (Sr) chemistry that has been shown in numerous studies to super-hydrophilicity in the early osseointegration of moderately rough-surfaced clinical oral implants (SLA(®) implant) in rabbit cancellous bone.
Hydrothermal treatment was performed to incorporate Sr ions into the surface of clinical SLA implants (SLA/Sr implant). The surface characteristics were evaluated by using field emission-scanning electron microscopy, X-ray photoelectron spectroscopy and optical profilometry. Twenty screw implants (10 control and 10 experimental) were placed in the femoral condyles of 10 New Zealand White rabbits. The early osseointegration of the SLA/Sr implant was compared with a chemically modified super-hydrophilic SLA implant (SLActive(®) implant) by histomorphometric and resonance frequency analysis after 2 weeks of implantation.
The SLA/Sr and SLActive implants exhibited an identical surface topography and average R(a) values at the micron and submicron scales. The SLA/Sr implant displayed a high amount of surface Sr content (15.6 at.%). There was no significant difference in the implant stability quotient (ISQ) values between the two groups. However, histomorphometric analysis revealed a significantly higher bone-to-implant contact percentage in the SLA/Sr implants compared with the SLActive implants in rabbit cancellous bone (P < 0.01).
The results indicate that the surface Sr chemistry surpasses the effect of super-hydrophilicity in promoting the early bone apposition of moderately rough Ti surface in cancellous bone.
目前尚不清楚在具有相同微观和亚微观表面形貌的微结构钛植入物中，表面生物活性化学或亲水性在骨整合中起更主导作用。为了了解它们在增强微粗糙表面植入物早期骨整合方面的相对效果，本研究比较了表面锶（Sr）化学对早期骨整合的促进作用，大量研究表明，表面锶化学具有超亲水性，可促进中度粗糙表面临床口腔植入物（SLA（®）植入物）在兔松质骨中的早期骨整合。
采用水热处理将 Sr 离子掺入临床 SLA 植入物（SLA/Sr 植入物）表面。采用场发射扫描电子显微镜、X 射线光电子能谱和光学轮廓仪评估表面特性。将 20 个螺钉植入物（10 个对照和 10 个实验）分别植入 10 只新西兰白兔的股骨髁。植入后 2 周，通过组织形态计量学和共振频率分析比较 SLA/Sr 植入物与化学改性超亲水 SLA 植入物（SLActive（®）植入物）的早期骨整合。
SLA/Sr 和 SLActive 植入物在微米和亚微米尺度上具有相同的表面形貌和平均 R（a）值。SLA/Sr 植入物表面 Sr 含量高（15.6 原子%）。两组间种植体稳定性系数（ISQ）值无显著差异。然而，组织形态计量学分析显示，在兔松质骨中，SLA/Sr 植入物的骨-种植体接触百分比明显高于 SLActive 植入物（P < 0.01）。
结果表明，表面 Sr 化学在促进松质骨中中度粗糙 Ti 表面的早期骨附着方面优于超亲水性。
