一种来自……的新型蛋白聚糖对能量代谢和线粒体生物发生的调节作用 。 （原文句子不完整，翻译可能会有些生硬，推测是想表达这样的意思）
Modulation of energy metabolism and mitochondrial biogenesis by a novel proteoglycan from .
作者信息
Yang Zhou, Zhang Zeng, Zhao Juan, He Yanming, Yang Hongjie, Zhou Ping
机构信息
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University Shanghai 200433 P. R. China
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 200437 P. R. China
出版信息
RSC Adv. 2019 Jan 18;9(5):2591-2598. doi: 10.1039/c8ra09482a.
In this study we first focused on the effects of a novel proteoglycan extracted from () on mitochondrial biogenesis, because mitochondrial dysfunction is highly related to insulin resistance. We found that can decrease ROS levels and increase ATP content in rat skeletal muscle L6 cells. In PGC-1α silent cells, increased expression of PGC-1α and positively modulated the Sirt1/PGC-1α pathway. Moreover, orally administered up-regulated the mitochondrial DNA (mtDNA) copy number and the related gene expressions that control mitochondrial biogenesis in ob/ob mice. Our work well elucidated the mechanism of ameliorating insulin resistance in the aspect of energy metabolism.
在本研究中，我们首先聚焦于从（）中提取的一种新型蛋白聚糖对线粒体生物合成的影响，因为线粒体功能障碍与胰岛素抵抗高度相关。我们发现（该蛋白聚糖）可降低大鼠骨骼肌L6细胞中的活性氧水平并增加ATP含量。在PGC - 1α沉默细胞中，（该蛋白聚糖）增加了PGC - 1α的表达并正向调节Sirt1/PGC - 1α通路。此外，口服（该蛋白聚糖）可上调ob/ob小鼠的线粒体DNA（mtDNA）拷贝数以及控制线粒体生物合成的相关基因表达。我们的工作很好地阐明了（该蛋白聚糖）在能量代谢方面改善胰岛素抵抗的机制。
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