Zhu Anlian, Wang Tong, Feng Wanlu, Wang Jianji, Li Lingjun
School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Normal University Xinxiang Henan 453007 P. R. China
RSC Adv. 2020 Aug 27;10(52):31662-31669. doi: 10.1039/d0ra05374k. eCollection 2020 Aug 21.
An ionic liquid, namely [Betaine][HPO], was found to be an efficient catalyst for the direct substitution reaction of xanthen-9-ol with different nucleophiles under solvent-free conditions. This catalytic system is easy to be operated and the following work-up procedure is simple, with the ionic liquid catalyst reusable for at least five cycles at a high catalytic activity level. In addition, the ionic liquid is easy to prepare and its raw materials are inexpensive and have good biocompatibility. Therefore, our study presents an intriguing and sustainable protocol for the direct substitution of alcohol.
一种离子液体，即[甜菜碱][HPO]，被发现是在无溶剂条件下氧杂蒽-9-醇与不同亲核试剂直接取代反应的有效催化剂。该催化体系易于操作，后续的后处理程序简单，离子液体催化剂可在高催化活性水平下重复使用至少五个循环。此外，该离子液体易于制备，其原料价格低廉且具有良好的生物相容性。因此，我们的研究提出了一种有趣且可持续的醇直接取代方案。
