D-糖炔酮衍生物的合成——羰基化Sonogashira反应
Synthesis of d-glyco-alkynone derivatives carbonylative Sonogashira reaction.
作者信息
Darbem Mariana P, Esteves C Henrique A, de Oliveira Isadora M, Reis Joel S, Pimenta Daniel C, Stefani Hélio A
机构信息
Faculdade de Ciências Farmacêuticas, Universidade de São Paulo São Paulo SP Brazil
Instituto de Química, Universidade de São Paulo São Paulo SP Brazil.
出版信息
RSC Adv. 2019 Mar 25;9(17):9468-9474. doi: 10.1039/c9ra00523d. eCollection 2019 Mar 22.
A carbonylative Sonogashira coupling approach to the synthesis of glyco-alkynones is described. Eighteen examples were obtained in moderate do nearly quantitative yields under mild conditions employing Mo(CO) as a safe carbon monoxide source. Functionalization of the alkynyl moiety cycloaddition with organic azides provided six examples of glyco-triazoles.
描述了一种用于合成糖基炔酮的羰基化Sonogashira偶联方法。在温和条件下，以Mo(CO)作为安全的一氧化碳源，获得了18个实例，产率中等至几乎定量。炔基部分的官能化与有机叠氮化物的环加成提供了6个糖基三唑的实例。
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