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钯催化芳基噻蒽鎓盐与芳基炔烃的羰基化Sonogashira偶联反应

Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Thianthrenium Salts with Arylalkynes.

作者信息

Zhao Yan-Hua, Gu Xing-Wei, Wu Xiao-Feng

机构信息

Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straße 29a, 18059 Rostock, Germany.

Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China.

出版信息

Org Lett. 2024 Aug 2;26(30):6507-6511. doi: 10.1021/acs.orglett.4c02440. Epub 2024 Jul 18.

DOI:10.1021/acs.orglett.4c02440
PMID:39023056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11301662/
Abstract

Alkynones are valuable compounds with applications in various areas. In this work, we developed an efficient carbonylation procedure for the carbonylative cross-coupling of aryl thianthrenium salts with aromatic alkynes. Various useful alkynones were produced in moderate to excellent yields under mild conditions. Notably, among the various tolerated functional groups, the bromide group can be maintained, which is ready for further coupling reactions.

摘要

炔酮是在各个领域都有应用的重要化合物。在这项工作中，我们开发了一种高效的羰基化方法，用于芳基噻蒽鎓盐与芳香炔烃的羰基化交叉偶联反应。在温和条件下，各种有用的炔酮以中等至优异的产率生成。值得注意的是，在各种可耐受的官能团中，溴基团可以保留，这便于进行进一步的偶联反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/4b173e4bbdbf/ol4c02440_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/2c783a5e6b6c/ol4c02440_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/72e895007a3e/ol4c02440_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/1db640d03f08/ol4c02440_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/7c4f285e426c/ol4c02440_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/4b173e4bbdbf/ol4c02440_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/2c783a5e6b6c/ol4c02440_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/72e895007a3e/ol4c02440_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/1db640d03f08/ol4c02440_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/7c4f285e426c/ol4c02440_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1164/11301662/4b173e4bbdbf/ol4c02440_0005.jpg

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