地夫可特及其前体的快速合成与初步抗菌活性
Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors.
作者信息
Esposito Anna, De Gregorio Eliana, De Fenza Maria, D'Alonzo Daniele, Satawani Anil, Guaragna Annalisa
机构信息
Department of Chemical Sciences, University of Napoli Federico II Via Cintia 80126 Napoli Italy
Department of Molecular Medicine and Medical Biotechnologies Via S. Pansini, 5 80131 Napoli Italy.
出版信息
RSC Adv. 2019 Jul 10;9(37):21519-21524. doi: 10.1039/c9ra03673c. eCollection 2019 Jul 5.
The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens and is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria.
本文报道了地夫可特（DFZ）的合成及其对人类病原体的微生物活性的初步评估。虽然DFZ无活性，但其一种合成前体对革兰氏阴性菌和革兰氏阳性菌均表现出较强的抗菌活性。
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