Esposito Anna, Migliaccio Antonella, Iula Vita Dora, Zarrilli Raffaele, Guaragna Annalisa, De Gregorio Eliana
Department of Chemical, Materials and Production Engineering, University of Naples Federico II, 80126 Naples, Italy.
Department of Public Health, University of Naples Federico II, 80131 Naples, Italy.
Antibiotics (Basel). 2021 Nov 13;10(11):1396. doi: 10.3390/antibiotics10111396.
Invasive infections have become a global public health problem due to the increase of species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity against various bacterial taxa. Consequently, it might be considered for the treatment of infections. The antifungal activity of PYED-1 was evaluated against several fungal strains that were representative of the five species that causes the majority of infections-namely, , , , and . PYED-1 exhibited a weak antifungal activity and a fungistatic effect on all five species. On the other hand, PYED-1 exhibited a good anti-biofilm activity, and was able to eradicate the preformed biofilms of all species analyzed. Moreover, PYED-1 inhibited germ tube and hyphae formation of and reduced adhesion of to abiotic surfaces by up to 30%.
由于对抗真菌治疗产生耐药性的物种增加，侵袭性感染已成为一个全球公共卫生问题。糖皮质激素PYED-1（孕二烯-11-羟基-16α,17α-环氧-3,20-二酮-1）对多种细菌类群具有抗菌活性。因此，它可能被考虑用于治疗感染。针对几种代表导致大多数感染的五个物种的真菌菌株，评估了PYED-1的抗真菌活性，这五个物种分别是、、、和。PYED-1对所有五个物种均表现出较弱的抗真菌活性和抑菌作用。另一方面，PYED-1表现出良好的抗生物膜活性，并且能够根除所分析的所有物种的预先形成的生物膜。此外，PYED-1抑制了和的芽管和菌丝形成，并使与非生物表面的粘附减少了高达30%。
