Yoshida Yohko, Shimizu Ippei, Hsiao Yung-Ting, Suda Masayoshi, Katsuumi Goro, Seki Masahide, Suzuki Yutaka, Okuda Shujiro, Soga Tomoyoshi, Minamino Tohru
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Department of Advanced Senotherapeutics, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
iScience. 2022 Apr 18;25(5):104268. doi: 10.1016/j.isci.2022.104268. eCollection 2022 May 20.
Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure. Although activation of brown/beige adipose tissue is associated with mobilization of both glucose and lipids, few studies have focused on the role of glycolytic enzymes in regulating adipose tissue function. We generated mouse models with specific deletion of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) from adipose tissue. Deletion of Pgam1 from both BAT and WAT promoted whitening of BAT with beiging of visceral WAT, whereas deletion of Pgam1 from BAT alone led to whitening of BAT without beiging of WAT. Our results demonstrate a potential role of glycolytic enzymes in beiging of visceral WAT and suggest that PGAM1 would be a novel therapeutic target in obesity and diabetes.
棕色脂肪组织（BAT）是一种代谢活跃的器官，有助于对寒冷暴露产生产热反应。此外，通过寒冷暴露，白色脂肪组织（WAT）中会产生另一种称为米色脂肪细胞的产热细胞。尽管棕色/米色脂肪组织的激活与葡萄糖和脂质的动员有关，但很少有研究关注糖酵解酶在调节脂肪组织功能中的作用。我们构建了从小鼠脂肪组织中特异性缺失糖酵解酶磷酸甘油酸变位酶1（PGAM1）的小鼠模型。从BAT和WAT中删除Pgam1会促进BAT变白，同时内脏WAT出现米色化，而仅从BAT中删除Pgam1会导致BAT变白，而WAT不会出现米色化。我们的结果证明了糖酵解酶在内脏WAT米色化中的潜在作用，并表明PGAM1可能是肥胖症和糖尿病的新型治疗靶点。
