Reitman Marc L
Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Cell Metab. 2017 Jul 5;26(1):14-16. doi: 10.1016/j.cmet.2017.06.011.
Fischer et al. (2017) recently reported that interleukin-4 (IL-4) does not increase adipose thermogenesis and that activated macrophages do not synthesize catecholamines. These findings are unexpected because IL-4 activation of macrophages has been proposed to have a pivotal role in cold-induced thermogenesis by stimulating macrophage catecholamine production to recruit thermogenic beige or brite fat.
菲舍尔等人（2017年）最近报告称，白细胞介素-4（IL-4）不会增加脂肪产热，活化的巨噬细胞也不会合成儿茶酚胺。这些发现出乎意料，因为有人提出巨噬细胞的IL-4活化在冷诱导产热中起关键作用，即通过刺激巨噬细胞产生儿茶酚胺来募集产热的米色或明亮脂肪。
