• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

苹果酸铬通过葡萄糖摄取和胰岛素敏感性信号通路改善3T3-L1脂肪细胞的高糖和胰岛素抵抗及其机制

Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism.

作者信息

Feng Weiwei, Liu Yongchao, Fei Fan, Chen Yao, Ding Yangyang, Yan Mengjiao, Feng Yun, Zhao Ting, Mao Guanghua, Yang Liuqing, Wu Xiangyang

机构信息

Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University 301 Xuefu Rd. 212013 Zhenjiang Jiangsu China

School of Medical Science and Laboratory Medicine, Jiangsu University 301 Xuefu Rd. 212013 Zhenjiang Jiangsu China.

出版信息

RSC Adv. 2018 Dec 21;9(1):114-127. doi: 10.1039/c8ra07470d. eCollection 2018 Dec 19.

DOI:10.1039/c8ra07470d
PMID:35521592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9059288/
Abstract

Previous study has revealed that chromium malate could improve insulin resistance and the regulation of fasting blood glucose in type 2 diabetic rats. This study was designed to investigate the effect of chromium malate on hypoglycemic and improve insulin resistance activities in 3T3-L1 adipocytes with insulin resistance and investigate the acting mechanism. The result indicated that chromium malate exhibited direct hypoglycemic activity . Compared with the model group, chromium malate could significantly promote the expression levels of GLUT-4, Akt, Irs-1, PPARγ, PI3K and p38-MAPK and their mRNA, increase -AKT/AKT level, AKT and AMPKβ1 phosphorylation and reduce Irs-1 phosphorylation and -Irs-1/Irs-1 level in 3T3-L1 adipocytes ( < 0.05). Chromium malate is more effective in regulating the proteins and mRNA expressions than those of chromium trichloride and chromium picolinate. Compared to the model group, pretreatment with the specific p38-MAPK inhibitor completely inhibited the GLUT-4 and Irs-1 proteins and mRNA expressions induced by the chromium malate. In conclusion, chromium malate had a beneficial influence on improvement of controlling glucose levels and insulin resistance in 3T3-L1 adipocytes with insulin resistance by regulating proteins productions and genes expressions in glucose uptake and insulin sensitivity signaling pathways.

摘要

先前的研究表明，苹果酸铬可改善2型糖尿病大鼠的胰岛素抵抗及空腹血糖调节。本研究旨在探讨苹果酸铬对胰岛素抵抗的3T3-L1脂肪细胞的降糖及改善胰岛素抵抗活性的作用，并研究其作用机制。结果表明，苹果酸铬具有直接降糖活性。与模型组相比，苹果酸铬可显著促进3T3-L1脂肪细胞中GLUT-4、Akt、Irs-1、PPARγ、PI3K和p38-MAPK及其mRNA的表达水平，增加-AKT/AKT水平、AKT和AMPKβ1磷酸化水平，并降低Irs-1磷酸化水平和-Irs-1/Irs-1水平（P<0.05）。苹果酸铬在调节蛋白质和mRNA表达方面比三氯化铬和吡啶甲酸铬更有效。与模型组相比，用特异性p38-MAPK抑制剂预处理可完全抑制苹果酸铬诱导的GLUT-4和Irs-1蛋白及mRNA表达。总之，苹果酸铬通过调节葡萄糖摄取和胰岛素敏感性信号通路中的蛋白质生成和基因表达，对改善胰岛素抵抗的3T3-L1脂肪细胞的血糖控制和胰岛素抵抗具有有益影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/2b7fbc1ed603/c8ra07470d-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/1fc06bb79bc3/c8ra07470d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/86332f99927d/c8ra07470d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/8b0c6b804a5b/c8ra07470d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/e5194fa34ca8/c8ra07470d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/6f8db64e3951/c8ra07470d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/6e74d7c8a8ef/c8ra07470d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/7a181a20daca/c8ra07470d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/748502fee280/c8ra07470d-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/2b7fbc1ed603/c8ra07470d-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/1fc06bb79bc3/c8ra07470d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/86332f99927d/c8ra07470d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/8b0c6b804a5b/c8ra07470d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/e5194fa34ca8/c8ra07470d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/6f8db64e3951/c8ra07470d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/6e74d7c8a8ef/c8ra07470d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/7a181a20daca/c8ra07470d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/748502fee280/c8ra07470d-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c237/9059288/2b7fbc1ed603/c8ra07470d-f9.jpg

相似文献

1
Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism.苹果酸铬通过葡萄糖摄取和胰岛素敏感性信号通路改善3T3-L1脂肪细胞的高糖和胰岛素抵抗及其机制
RSC Adv. 2018 Dec 21;9(1):114-127. doi: 10.1039/c8ra07470d. eCollection 2018 Dec 19.
2
Chromium malate alleviates high-glucose and insulin resistance in L6 skeletal muscle cells by regulating glucose uptake and insulin sensitivity signaling pathways.苹果酸铬通过调节葡萄糖摄取和胰岛素敏感性信号通路缓解 L6 骨骼肌细胞的高葡萄糖和胰岛素抵抗。
Biometals. 2018 Oct;31(5):891-908. doi: 10.1007/s10534-018-0132-4. Epub 2018 Jul 16.
3
Effects of chromium picolinate on glucose uptake in insulin-resistant 3T3-L1 adipocytes involve activation of p38 MAPK.吡啶甲酸铬对胰岛素抵抗 3T3-L1 脂肪细胞葡萄糖摄取的影响涉及 p38 MAPK 的激活。
J Nutr Biochem. 2009 Dec;20(12):982-91. doi: 10.1016/j.jnutbio.2008.09.002. Epub 2009 Feb 5.
4
Type 2 diabetic rats on diet supplemented with chromium malate show improved glycometabolism, glycometabolism-related enzyme levels and lipid metabolism.在饮食中补充苹果酸铬的2型糖尿病大鼠，其糖代谢、糖代谢相关酶水平及脂质代谢均得到改善。
PLoS One. 2015 May 5;10(5):e0125952. doi: 10.1371/journal.pone.0125952. eCollection 2015.
5
Kutkin, iridoid glycosides enriched fraction of Picrorrhiza kurroa promotes insulin sensitivity and enhances glucose uptake by activating PI3K/Akt signaling in 3T3-L1 adipocytes.库尔蒂宁，富含胡黄连属环烯醚萜苷的提取物可通过激活 3T3-L1 脂肪细胞中的 PI3K/Akt 信号通路促进胰岛素敏感性并增强葡萄糖摄取。
Phytomedicine. 2022 Aug;103:154204. doi: 10.1016/j.phymed.2022.154204. Epub 2022 May 25.
6
Melatonin rescues 3T3-L1 adipocytes from FFA-induced insulin resistance by inhibiting phosphorylation of IRS-1 on Ser307.褪黑素通过抑制胰岛素受体底物-1（IRS-1）第307位丝氨酸的磷酸化，使3T3-L1脂肪细胞免受游离脂肪酸（FFA）诱导的胰岛素抵抗。
Biochimie. 2014 Aug;103:126-30. doi: 10.1016/j.biochi.2014.05.001. Epub 2014 May 15.
7
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.地塞米松诱导的3T3-L1脂肪细胞胰岛素抵抗是由于葡萄糖转运受抑制，而非胰岛素信号转导受抑制。
Diabetes. 2000 Oct;49(10):1700-8. doi: 10.2337/diabetes.49.10.1700.
8
α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway.α-硫辛酸通过 IRS-1/Akt 信号通路改善 LYRM1 过表达 3T3-L1 脂肪细胞的葡萄糖摄取受损。
J Bioenerg Biomembr. 2012 Oct;44(5):579-86. doi: 10.1007/s10863-012-9460-1. Epub 2012 Jul 22.
9
Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation.来自青钱柳（胡桃科）的两种三萜类化合物促进3T3-L1脂肪细胞对葡萄糖的摄取：与AMPK激活的关系。
Phytomedicine. 2015 Aug 15;22(9):837-46. doi: 10.1016/j.phymed.2015.05.058. Epub 2015 Jun 20.
10
Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.雷帕霉素哺乳动物靶点通路的激活会急性抑制3T3-L1细胞和人脂肪细胞中胰岛素向Akt的信号传导以及葡萄糖转运。
Endocrinology. 2005 Mar;146(3):1328-37. doi: 10.1210/en.2004-0777. Epub 2004 Dec 2.

引用本文的文献

1
Trivalent chromium versus baricitinib for rheumatoid arthritis treatment: first phase 2/3 randomized controlled trial, is trivalent chromium the upcoming immune-modulator?三价铬对比巴瑞替尼治疗类风湿关节炎：首个 2/3 期随机对照试验，三价铬是否即将成为新型免疫调节剂？
Inflammopharmacology. 2024 Oct;32(5):3163-3179. doi: 10.1007/s10787-024-01515-x. Epub 2024 Jul 19.
2
Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus.中药治疗糖尿病评价指标和作用机制研究进展。
Animal Model Exp Med. 2024 Aug;7(4):433-443. doi: 10.1002/ame2.12455. Epub 2024 Jul 7.
3

本文引用的文献

1
Dietary polyphenol canolol from rapeseed oil attenuates oxidative stress-induced cell damage through the modulation of the p38 signaling pathway.菜籽油中的膳食多酚油菜素通过调节p38信号通路减轻氧化应激诱导的细胞损伤。
RSC Adv. 2018 Jul 5;8(43):24338-24345. doi: 10.1039/c8ra04130j. eCollection 2018 Jul 2.
2
Apoptosis in pancreatic β-cells is induced by arsenic and atorvastatin in Wistar rats with diabetes mellitus type 2.砷和阿托伐他汀诱导 2 型糖尿病 Wistar 大鼠胰岛 β 细胞凋亡。
J Trace Elem Med Biol. 2018 Mar;46:144-149. doi: 10.1016/j.jtemb.2017.12.008. Epub 2017 Dec 23.
3
Alantolactone Improves Prolonged Exposure of Interleukin-6-Induced Skeletal Muscle Inflammation Associated Glucose Intolerance and Insulin Resistance.
Insulin Resistance Model: A Recent Update.
胰岛素抵抗模型：最新进展。
J Obes. 2023 Jan 18;2023:1964732. doi: 10.1155/2023/1964732. eCollection 2023.
4
Trivalent chromium supplementation ameliorates adjuvant induced rheumatoid arthritis through up-regulation of FOXP3 and decrease in synovial Cathepsin G expression.三价铬补充剂通过上调 FOXP3 和降低滑膜组织组织蛋白酶 G 的表达来改善佐剂诱导的类风湿关节炎。
Inflammopharmacology. 2022 Dec;30(6):2181-2195. doi: 10.1007/s10787-022-01025-8. Epub 2022 Jul 13.
5
Amelioration of type 2 diabetes by the novel 6, 8-guanidyl luteolin quinone-chromium coordination via biochemical mechanisms and gut microbiota interaction.新型 6,8-胍基木犀草素醌-铬配合物通过生化机制和肠道微生物群相互作用改善 2 型糖尿病。
J Adv Res. 2023 Apr;46:173-188. doi: 10.1016/j.jare.2022.06.003. Epub 2022 Jun 11.
土木香内酯可改善白细胞介素-6诱导的骨骼肌炎症相关的葡萄糖不耐受和胰岛素抵抗的长期暴露。
Front Pharmacol. 2017 Jun 29;8:405. doi: 10.3389/fphar.2017.00405. eCollection 2017.
4
Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line.槲皮素，一种抗2型糖尿病的先导化合物，通过AMPK途径改善骨骼肌细胞系中的葡萄糖摄取。
Front Pharmacol. 2017 Jun 8;8:336. doi: 10.3389/fphar.2017.00336. eCollection 2017.
5
Ambient Air Pollution and Type 2 Diabetes: Do the Metabolic Effects of Air Pollution Start Early in Life?环境空气污染与2型糖尿病：空气污染的代谢影响是否在生命早期就已开始？
Diabetes. 2017 Jul;66(7):1755-1757. doi: 10.2337/dbi17-0012.
6
Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate.2型糖尿病中的基因-饮食相互作用：先有鸡还是先有蛋的争论。
Int J Mol Sci. 2017 Jun 2;18(6):1188. doi: 10.3390/ijms18061188.
7
Specific visible radiation facilitates lipolysis in mature 3T3-L1 adipocytes via rhodopsin-dependent β3-adrenergic signaling.特定的可见辐射通过视紫红质依赖性β3-肾上腺素能信号通路促进成熟3T3-L1脂肪细胞的脂肪分解。
Eur J Cell Biol. 2017 Jun;96(4):301-311. doi: 10.1016/j.ejcb.2017.03.015. Epub 2017 Apr 27.
8
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.黄腐酚和8-异戊烯基柚皮素可改善小鼠糖尿病相关的代谢功能障碍。
J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6.
9
Effect of Peroral Administration of Chromium on Insulin Signaling Pathway in Skeletal Muscle Tissue of Holstein Calves.口服铬对荷斯坦犊牛骨骼肌组织胰岛素信号通路的影响。
Biol Trace Elem Res. 2017 Dec;180(2):223-232. doi: 10.1007/s12011-017-1007-1. Epub 2017 Apr 4.
10
Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway.黄芩苷通过激活AKT/AS160/GLUT4信号通路对抗肥胖和胰岛素抵抗。
Mol Cell Endocrinol. 2017 Jun 15;448:77-86. doi: 10.1016/j.mce.2017.03.027. Epub 2017 Mar 27.