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超高效液相色谱-四极杆轨道阱串联质谱法及多元统计分析比较三种炮制西洋参产品中的皂苷成分

Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis.

作者信息

Guo Na, Bai Yuxin, Huang Xin, Liu Xiaokang, Cai Guangzhi, Liu Shuying, Guo Yunlong, Gong Jiyu

机构信息

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.

School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China.

出版信息

Int J Anal Chem. 2022 Apr 26;2022:6721937. doi: 10.1155/2022/6721937. eCollection 2022.

DOI:10.1155/2022/6721937
PMID:35521625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9064508/
Abstract

A method with ultrahigh performance liquid chromatography Quadrupole-Orbitrap tandem mass spectrometry (UHPLC-Q-Orbitrap-MS/MS) was applied for the quality evaluation of different processing and drying of American ginseng, including natural drying (ND), steam drying (SD), and vacuum freeze-drying (VFD). A total of 51 saponins were successfully identified in three processed products. Three processed American ginseng products were well-differentiated in orthogonal partial least-squares discriminant analysis (OPLS-DA). The S-plot also identified the marker compounds in each product, while the major ginsenosides of ND (malonyl (M)-Rd, M-Rb, Rg), SD (20 (S)-Rg, 20 (S)-Rg), and VFD (M-Rd, M-Rb) were found. The results indicate that the method by vacuum freeze-drying can retain the content of rare ginsenosides and malonyl-ginsenosides. The marker compounds selected will benefit the holistic evaluation of related American ginseng products.

摘要

采用超高效液相色谱四极杆-轨道阱串联质谱法（UHPLC-Q-Orbitrap-MS/MS）对西洋参不同加工和干燥方式（包括自然干燥（ND）、蒸汽干燥（SD）和真空冷冻干燥（VFD））进行质量评价。在三种加工产品中成功鉴定出51种皂苷。在正交偏最小二乘法判别分析（OPLS-DA）中，三种加工的西洋参产品得到了很好的区分。S-图还确定了每种产品中的标志性化合物，同时发现了自然干燥产品（丙二酰（M）-Rd、M-Rb、Rg）、蒸汽干燥产品（20（S）-Rg、20（S）-Rg）和真空冷冻干燥产品（M-Rd、M-Rb）中的主要人参皂苷。结果表明，真空冷冻干燥方法可以保留稀有人参皂苷和丙二酰人参皂苷的含量。所选择的标志性化合物将有助于对相关西洋参产品进行整体评价。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/3e42d38e7d60/IJAC2022-6721937.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/d8616d1a29e8/IJAC2022-6721937.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/aca5229d5bf2/IJAC2022-6721937.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/d75ae75974aa/IJAC2022-6721937.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/13a6545d6966/IJAC2022-6721937.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/3e42d38e7d60/IJAC2022-6721937.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/d8616d1a29e8/IJAC2022-6721937.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/aca5229d5bf2/IJAC2022-6721937.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/d75ae75974aa/IJAC2022-6721937.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/13a6545d6966/IJAC2022-6721937.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/9064508/3e42d38e7d60/IJAC2022-6721937.005.jpg

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引用本文的文献

[1]
Comparing the Drying Characteristics, Phytochemicals, and Antioxidant Characterization of L. Treated by Different Processing Techniques.

Foods. 2025-2-27

[2]
Comprehensive Investigation of Ginsenosides in the Steamed with Different Processing Conditions Using LC-MS.

Molecules. 2024-1-28

本文引用的文献

[1]
Evaluation of storage period of fresh ginseng for quality improvement of dried and red processed varieties.

J Ginseng Res. 2022-3

[2]
A general procedure for establishing composite quality evaluation indices based on key quality attributes of traditional Chinese medicine.

J Pharm Biomed Anal. 2022-1-5

[3]
Application of vermicompost and biochar suppresses Fusarium root rot of replanted American ginseng.

Appl Microbiol Biotechnol. 2021-9

[4]
Comparison of Essential Oils of Thunb. from Different Processing Methods and Harvest Seasons Based on GC-MS and Chemometric Analysis.

Int J Anal Chem. 2021-7-16

[5]
Non-targeted metabonomics to investigate the differences in the properties of ginseng and American ginseng based on rapid resolution liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.

J Sep Sci. 2021-9

[6]
Classification-based strategies to simplify complex traditional Chinese medicine (TCM) researches through liquid chromatography-mass spectrometry in the last decade (2011-2020): Theory, technical route and difficulty.

J Chromatogr A. 2021-8-16

[7]
The Synergistic Effects of Polysaccharides and Ginsenosides From American Ginseng ( L.) Ameliorating Cyclophosphamide-Induced Intestinal Immune Disorders and Gut Barrier Dysfunctions Based on Microbiome-Metabolomics Analysis.

Front Immunol. 2021

[8]
Comprehensive Quality Evaluation of American Ginseng for Different Parts and Abnormal Trait Based on the Major Ginsenoside Contents and Morphological Characteristics.

Biomed Res Int. 2021

[9]
Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from American ginseng and prepared by heating and acid treatment.

J Ginseng Res. 2021-1

[10]
(North American Ginseng) Polysaccharides as Immunomodulators: Current Research Status and Future Directions.

Molecules. 2020-12-11

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