Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China.
Dis Markers. 2022 Apr 26;2022:7512736. doi: 10.1155/2022/7512736. eCollection 2022.
Bacterial liver abscess (BLA) is a secondary infectious disease caused by hepatic parenchymal inflammation and bacterial necrosis. Studies have shown that diabetic patients with BLA have higher rates of related adverse events than patients without diabetes.
To explore the clinical characteristics of BLA complicated with diabetes and nondiabetes-related BLA.
From January 2019 to June 2020, 61 diabetic patients with BLA were included as the study group, and 61 BLA patients without diabetes were included as the control group. Clinical manifestations, laboratory examination index (prothrombin activity (PTA), albumin (propagated), white blood cell count (WBC), red blood cell count (RBC), plasma fibrinogen (FIB), C-reactive protein (CRP), neutrophil percentage (NEUT), and prealbumin (PA)) levels, blood cultivation, and fester situation in the two groups were analyzed.
No differences of Fever, right upper abdominal pain, jaundice, vomiting and nausea, liver tenderness, and liver pain upon percussion were observed between the study and control groups. However, chill, cough and expectoration, and liver pain upon percussion were higher in the study group, while abdominal distension was lower. WBC, RBC, PA, PTA, FIB, and CRP were higher than the control group. NEUT was higher in the study group than in the control group and Alb was lower than that in the control group. There was no significant difference between the positivity of blood bacterial culture in the study and control groups. The positivity rate of in Gram-negative aerobic bacteria in the study group was higher than that in the control group. There was no significant difference between the positivity of fester culture of the two groups. The positivity of in Gram-negative aerobic bacteria in the study group was higher than that in the control group. The positivity of was lower in the study group than in the control group.
Clinical manifestations and laboratory results of BLA patients with and without diabetes mellitus were significantly different. The symptoms of diabetics with BLA were serious.
细菌性肝脓肿（BLA）是一种由肝实质炎症和细菌坏死引起的继发性感染性疾病。研究表明，患有 BLA 的糖尿病患者比没有糖尿病的患者发生相关不良事件的比率更高。
探讨糖尿病合并细菌性肝脓肿与非糖尿病相关细菌性肝脓肿的临床特点。
选取 2019 年 1 月至 2020 年 6 月收治的 61 例糖尿病合并细菌性肝脓肿患者为观察组，同期收治的 61 例非糖尿病细菌性肝脓肿患者为对照组。比较两组患者的临床表现、实验室检查指标（凝血酶原活动度（PTA）、白蛋白（propagated）、白细胞计数（WBC）、红细胞计数（RBC）、血浆纤维蛋白原（FIB）、C 反应蛋白（CRP）、中性粒细胞百分比（NEUT）、前白蛋白（PA））水平、血培养结果及脓肿情况。
观察组发热、右上腹痛、黄疸、呕吐及恶心、肝区压痛、肝区叩击痛与对照组比较，差异无统计学意义；观察组畏寒、咳嗽咳痰、肝区叩击痛较对照组高，而腹胀较对照组低。观察组 WBC、RBC、PA、PTA、FIB、CRP 高于对照组，NEUT 高于对照组，Alb 低于对照组。两组血细菌培养阳性率比较，差异无统计学意义；观察组革兰阴性需氧菌阳性率高于对照组。两组脓肿培养阳性率比较，差异无统计学意义；观察组革兰阴性需氧菌阳性率高于对照组，真菌阳性率低于对照组。
糖尿病合并细菌性肝脓肿患者与非糖尿病细菌性肝脓肿患者的临床表现及实验室结果存在明显差异，糖尿病合并细菌性肝脓肿患者的症状更严重。
