Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Eur J Endocrinol. 2022 Jun 1;187(1):135-142. doi: 10.1530/EJE-21-0999.
Little is known about the ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) during infancy. This study aimed to evaluate serum and urinary LH/FSH as a marker of sex with age-specific cutoffs in healthy infants.
A prospective, longitudinal cohort study of healthy infants aged 0-1.2 years.
In total, 236 healthy infants (122 boys and 114 girls) from The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), with 567 serum and 603 urine samples, were included. Measures of diagnostic accuracy, including sensitivity and specificity, were used to assess the ability of LH/FSH to detect sex in healthy infants.
In both serum and urine, LH/FSH was highest in males with minimal overlap between the sexes. In contrast to isolated LH and FSH concentrations, LH/FSH ratios in both serum and urine were excellent markers of sex from 0 to 1.2 years with median sensitivities and specificities ranging from 93 to 100% with correspondingly narrow 95% CIs.
Serum and urinary LH/FSH ratios are excellent discriminators of sex in healthy infants during the entire first year of life. The clinical role and application of the ratio remain to be elucidated.
婴儿期促黄体生成素（LH）和卵泡刺激素（FSH）的比值知之甚少。本研究旨在评估血清和尿 LH/FSH 作为健康婴儿性别标记物的特征，并确定年龄特异性截断值。
一项针对 0-1.2 岁健康婴儿的前瞻性、纵向队列研究。
共纳入来自哥本哈根迷你青春期研究（ClinicalTrials.gov ID：NCT02784184）的 236 名健康婴儿（122 名男婴和 114 名女婴），其中有 567 份血清样本和 603 份尿液样本。采用诊断准确性指标，包括敏感性和特异性，评估 LH/FSH 检测健康婴儿性别的能力。
在血清和尿液中，LH/FSH 在男性中最高，男女之间几乎没有重叠。与单独的 LH 和 FSH 浓度相比，血清和尿液中的 LH/FSH 比值均是 0-1.2 岁性别极好的标记物，其敏感性和特异性中位数范围从 93%到 100%，相应的 95%CI 较窄。
在整个婴儿期的第一年，血清和尿 LH/FSH 比值是健康婴儿性别极好的鉴别指标。该比值的临床作用和应用仍有待阐明。
