伴有 Roth 斑的 MOG 抗体相关视神经炎非典型病例。
Atypical Case of MOG Antibody-Associated Optic Neuritis with Roth Spots.
作者信息
Aboab Jennifer, Errera Marie-Hélène, Espinoza Sophie, Girmens Jean-François, Héron Emmanuel
机构信息
Department of Internal Medecine, Centre Hospitalier National des Quinze-Vingts, Paris Cedex, France.
Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
出版信息
Ocul Immunol Inflamm. 2023 Jul;31(5):1068-1072. doi: 10.1080/09273948.2022.2062386. Epub 2022 May 6.
PURPOSE
To report an atypical case of MOG antibody-associated optic neuritis with Roth spots and widespread retinal hemorrhages.
CASE REPORT
A 49-year-old woman complained of 1 week history painful visual loss in the left eye. Funduscopy exam showed a severe optic disc edema associated with multiple peripapillar hemorrhages, peripheral retinal hemorrhages and Roth spots in the left eye. Orbit MRI revealed an hyperintensity in the left optic nerve, enhanced with gadolinium. The serum Myelin Oligodendrocyte (MOG) antibodies was found positive. Early intravenous high dose of steroids rapidly improved visual acuity and fundus abnormalities rapidly resolved.
CONCLUSION
Retinal hemorrhages can also be detected in case of optic disc edema associated with an optic neuritis, as seen in MOGAD.
目的
报告一例伴有 Roth 斑和广泛视网膜出血的 MOG 抗体相关视神经炎非典型病例。
病例报告
一名 49 岁女性主诉左眼有 1 周的疼痛性视力丧失病史。眼底镜检查显示左眼严重视盘水肿，伴有多个视乳头周围出血、周边视网膜出血和 Roth 斑。眼眶 MRI 显示左侧视神经高信号，钆增强。血清髓鞘少突胶质细胞（MOG）抗体检测呈阳性。早期静脉注射大剂量类固醇迅速提高了视力，眼底异常迅速消失。
结论
如在 MOGAD 中所见，视神经炎相关视盘水肿的病例中也可检测到视网膜出血。
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