较高的饮食炎症指数评分与大脑 MRI 脑老化标志物相关：弗雷明汉心脏研究后代队列的研究结果。
Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort.
机构信息
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas, USA.
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
出版信息
Alzheimers Dement. 2023 Feb;19(2):621-631. doi: 10.1002/alz.12685. Epub 2022 May 6.
INTRODUCTION
We investigated cross-sectional associations between the Dietary Inflammatory Index (DII) and measures of brain volume and cerebral small vessel disease among participants of the Framingham Heart Study Offspring cohort.
METHODS
A total of 1897 participants (mean ± standard deviation, age 62±9) completed Food Frequency Questionnaires and brain magnetic resonance imaging (MRI).
RESULTS
Higher (pro-inflammatory) DII scores, averaged across a maximum of three time points, were associated with smaller total brain volume (beta ± standard error: -0.16 ± 0.03; P < .0001) after adjustment for demographic, clinical, and lifestyle covariates. In addition, higher DII scores were associated with smaller total gray matter volume (-0.08 ± 0.03; P = .003) and larger lateral ventricular volume (0.04 ± 0.02; P = .03). No associations were observed with other brain MRI measures.
DISCUSSION
Our findings showed associations between higher DII scores and global brain MRI measures. As we are one of the first groups to report on the associations between higher DII scores and brain volume, replication is needed to confirm our findings.
简介
我们研究了弗雷明汉心脏研究后代队列中饮食炎症指数（DII）与脑容量和脑小血管疾病测量值之间的横断面关联。
方法
共有 1897 名参与者（平均±标准差，年龄 62±9 岁）完成了食物频率问卷和脑部磁共振成像（MRI）。
结果
经过调整人口统计学、临床和生活方式因素后，DII 评分最高可达三个时间点的平均值与总脑容量较小有关（β±标准误差：-0.16±0.03；P<0.0001）。此外，较高的 DII 评分与总灰质体积较小（-0.08±0.03；P=0.003）和侧脑室体积较大有关（0.04±0.02；P=0.03）。与其他脑 MRI 测量值无关联。
讨论
我们的研究结果表明，较高的 DII 评分与全球脑 MRI 测量值之间存在关联。由于我们是第一批报告较高的 DII 评分与脑容量之间关联的研究组之一，需要进行复制以确认我们的研究结果。
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