DEPARTMENT HYGIENE AND ECOLOGY, IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE; ACCREDITED LABORATORY OF OCCUPATIONAL HEALTH AND SAFETY, WROCLAW UNIVERSITY OF SCIENCE TECHNOLOGY, WROCLAW, POLAND.
DEPARTMENT OF PHTHISIOLOGY AND PULMONOLOGY WITH COURSE OF OCCUPATIONAL DISEASES, IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.
Wiad Lek. 2022;75(3):670-677.
The aim: To analyse the structure of sensory impairments, associated with COVID-19. To identify terms of recovery periods depending on severity of disease, age and gender of the patients.
Materials and methods: Within two weeks, 2225 patients with confirmed COVID-19 completed a questionnaire, created by Google Forms. General complaints, peculiarities of sensory impairments and recovery time were specified. After exclusion criteria application, data of 2108 patients were analyzed by R Statistics Package, Student's t-test, Wilcoxon rank-sum test, Fisher's exact test, Spearman's rank test.
Results: Among patients enrolled (973 males and 1135 females, mean age 28.6±0.18) the most frequent were olfactory (91.32%) and gustatory (66.03%) dysfunctions. Olfactory manifestations were usually accompanied by gustatory disorders (73.72%). Average duration of olfactory dysfunction was 15.46±0.45 days, gustatory - 11.3±0.33, hearing - 4.3±0.16, and visual - 6.53±0.23 days. It was found a correlation between duration of olfactory and gustatory impairments (r=0.65; p < 0.001), hearing and visual disorders (r=0.49; p < 0.05).
Conclusions: Olfactory and gustatory disorders are prevalent symptoms in Ukrainian population. 7.87% of respondents who had impairment of all four sensory functions had the longest recovery time. Duration of sensory impairments did not depend on age, type of treatment and severity of disease, which rises the question about the neurogenic pathway of virus.
分析与 COVID-19 相关的感觉障碍结构。确定根据疾病严重程度、患者年龄和性别确定恢复时间的术语。
在两周内,2225 名确诊 COVID-19 的患者通过 Google 表格完成了一份问卷。患者明确了一般症状、感觉障碍的特点和恢复时间。应用排除标准后,2108 例患者的数据通过 R 统计软件包、学生 t 检验、Wilcoxon 秩和检验、Fisher 确切检验、Spearman 秩检验进行分析。
在纳入的患者中(973 名男性和 1135 名女性,平均年龄 28.6±0.18),最常见的是嗅觉(91.32%)和味觉(66.03%)障碍。嗅觉表现通常伴有味觉障碍(73.72%)。嗅觉障碍的平均持续时间为 15.46±0.45 天,味觉障碍为 11.3±0.33 天,听力障碍为 4.3±0.16 天,视觉障碍为 6.53±0.23 天。发现嗅觉和味觉障碍持续时间之间存在相关性(r=0.65;p < 0.001),听力和视觉障碍之间存在相关性(r=0.49;p < 0.05)。
嗅觉和味觉障碍是乌克兰人群中的常见症状。7.87%的四项感觉功能均受损的患者恢复时间最长。感觉障碍的持续时间与年龄、治疗类型和疾病严重程度无关,这引发了病毒神经通路的问题。