兔动脉粥样硬化进展过程中局部血流动力学和斑块成分的时空变化
Spatiotemporal changes of local hemodynamics and plaque components during atherosclerotic progression in rabbit.
作者信息
Li Xiaoyin, Liu Xiao, Liang Ye, Deng Xiaoyan, Fan Yubo
机构信息
Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
出版信息
Comput Methods Programs Biomed. 2022 Jun;220:106814. doi: 10.1016/j.cmpb.2022.106814. Epub 2022 Apr 13.
BACKGROUND AND OBJECTIVE
Recent evidence demonstrates that the atherogenic process is discontinuous. Our goal is to study changes of plaque components and local hemodynamics during atherosclerotic progression.
METHODS
The histological and immunohistochemical staining of high-fat diet rabbit aorta were evaluated at 0, 8, 10 and 12 weeks, respectively. In addition, the blood flow and LDL transport were simulated at the above four time points.
RESULTS
The plaque thickness at different characteristic regions increased at different rates. The collagen continued to increase, while the elastin, fibronectin, macrophages and smooth muscle cells increased first and then decreased. The relative surface LDL concentration decreased at 8 weeks, and then it increased first and decreased slightly. Meanwhile, the hemodynamic environment became better firstly at 8 weeks, then got slightly worse and lastly improved again.
CONCLUSIONS
The local hemodynamics and plaque components vary nonlinearly during atherosclerotic progression in rabbit aorta.
背景与目的
近期证据表明动脉粥样硬化形成过程是不连续的。我们的目标是研究动脉粥样硬化进展过程中斑块成分和局部血流动力学的变化。
方法
分别在0、8、10和12周对高脂饮食兔主动脉进行组织学和免疫组织化学染色评估。此外，在上述四个时间点模拟血流和低密度脂蛋白转运。
结果
不同特征区域的斑块厚度以不同速率增加。胶原蛋白持续增加，而弹性蛋白、纤连蛋白、巨噬细胞和平滑肌细胞先增加后减少。相对表面低密度脂蛋白浓度在8周时降低，然后先升高后略有下降。同时，血流动力学环境在8周时首先改善，然后略有恶化，最后再次改善。
结论
兔主动脉动脉粥样硬化进展过程中，局部血流动力学和斑块成分呈非线性变化。
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