• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate.极早产儿因治疗性扑热息痛剂量导致的急性肝衰竭。
BMJ Case Rep. 2022 May 6;15(5):e245406. doi: 10.1136/bcr-2021-245406.
2
Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate.一名极早产儿因治疗性对乙酰氨基酚给药继发急性肝衰竭。
Drug Ther Bull. 2024 Feb 28;62(3):43-47. doi: 10.1136/dtb.2023.245406rep.
3
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates.对乙酰氨基酚、布洛芬和吲哚美辛在早产儿动脉导管未闭封堵中的疗效和安全性比较研究。
Eur J Pediatr. 2017 Feb;176(2):233-240. doi: 10.1007/s00431-016-2830-7. Epub 2016 Dec 21.
4
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.对乙酰氨基酚（醋氨酚）用于早产儿或低出生体重儿动脉导管未闭的治疗。
Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4.
5
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.对早产儿或低出生体重儿的动脉导管未闭（patent ductus arteriosus），使用扑热息痛（acetaminophen，对乙酰氨基酚）。
Cochrane Database Syst Rev. 2022 Dec 15;12:CD010061. doi: 10.1002/14651858.CD010061.pub5.
6
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.对乙酰氨基酚（醋氨酚）用于早产儿或低出生体重儿动脉导管未闭。
Cochrane Database Syst Rev. 2018 Apr 6;4(4):CD010061. doi: 10.1002/14651858.CD010061.pub3.
7
Neurodevelopmental Outcomes of Preterm Infants Treated with Oral Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus.口服对乙酰氨基酚与布洛芬治疗早产儿动脉导管未闭的神经发育结局
Am J Perinatol. 2017 Oct;34(12):1185-1189. doi: 10.1055/s-0037-1601564. Epub 2017 Apr 10.
8
Oral ibuprofen is superior to oral paracetamol for patent ductus arteriosus in very low and extremely low birth weight infants.对于极低出生体重和超低出生体重的婴儿，口服布洛芬在治疗动脉导管未闭方面优于口服对乙酰氨基酚。
Medicine (Baltimore). 2019 Aug;98(31):e16689. doi: 10.1097/MD.0000000000016689.
9
Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: study protocol for a randomized control trial.静脉注射对乙酰氨基酚与布洛芬治疗早产儿动脉导管未闭的疗效和安全性比较：一项随机对照试验的研究方案
Trials. 2016 Apr 2;17:182. doi: 10.1186/s13063-016-1294-4.
10
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants.对乙酰氨基酚（扑热息痛）用于早产儿或低体重儿动脉导管未闭的治疗。
Cochrane Database Syst Rev. 2015 Mar 11(3):CD010061. doi: 10.1002/14651858.CD010061.pub2.

引用本文的文献

1
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.治疗儿童特发性药物性肝损伤和对乙酰氨基酚肝毒性的方法：系统评价。
Drug Saf. 2022 Nov;45(11):1329-1348. doi: 10.1007/s40264-022-01224-w. Epub 2022 Aug 25.

本文引用的文献

1
Early PARacetamol (EPAR) trial: a study protocol for a randomised controlled trial of early paracetamol to promote closure of the ductus arteriosus in preterm infants.早期扑热息痛（EPAR）试验：一项随机对照试验的研究方案，旨在研究早期扑热息痛对早产儿动脉导管未闭闭合的影响。
BMJ Open. 2019 Oct 30;9(10):e031428. doi: 10.1136/bmjopen-2019-031428.
2
Follow-up study of the early, randomised paracetamol trial to preterm infants, found no adverse reactions at the two-years corrected age.对早产儿进行的早期随机扑热息痛试验的随访研究发现，在纠正年龄 2 岁时没有不良反应。
Acta Paediatr. 2019 Mar;108(3):452-458. doi: 10.1111/apa.14614. Epub 2018 Nov 12.
3
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.对乙酰氨基酚（醋氨酚）用于早产儿或低出生体重儿动脉导管未闭。
Cochrane Database Syst Rev. 2018 Apr 6;4(4):CD010061. doi: 10.1002/14651858.CD010061.pub3.
4
Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?对乙酰氨基酚用于动脉导管未闭治疗：有效且安全吗？
Biomed Res Int. 2017;2017:1438038. doi: 10.1155/2017/1438038. Epub 2017 Jul 30.
5
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates.对乙酰氨基酚、布洛芬和吲哚美辛在早产儿动脉导管未闭封堵中的疗效和安全性比较研究。
Eur J Pediatr. 2017 Feb;176(2):233-240. doi: 10.1007/s00431-016-2830-7. Epub 2016 Dec 21.
6
Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis.对乙酰氨基酚用于治疗早产儿动脉导管未闭：一项系统评价和荟萃分析。
Arch Dis Child Fetal Neonatal Ed. 2016 Mar;101(2):F127-36. doi: 10.1136/archdischild-2014-307312. Epub 2015 Aug 17.
7
Enteral paracetamol or Intravenous Indomethacin for Closure of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial.肠内给予对乙酰氨基酚或静脉注射吲哚美辛用于早产儿动脉导管未闭的闭合：一项随机对照试验。
Indian Pediatr. 2015 Jul;52(7):573-8. doi: 10.1007/s13312-015-0677-z.
8
Preterm patent ductus arteriosus: A continuing conundrum for the neonatologist?早产动脉导管未闭：新生儿科医生面临的持续难题？
Semin Fetal Neonatal Med. 2015 Aug;20(4):272-7. doi: 10.1016/j.siny.2015.03.004. Epub 2015 Mar 25.
9
Associations between acetaminophen use during pregnancy and ADHD symptoms measured at ages 7 and 11 years.孕期对乙酰氨基酚的使用与7岁和11岁时测量的多动症症状之间的关联。
PLoS One. 2014 Sep 24;9(9):e108210. doi: 10.1371/journal.pone.0108210. eCollection 2014.
10
Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants.低剂量静脉注射对乙酰氨基酚对治疗早产儿动脉导管未闭也有效。
Cardiol Young. 2015 Aug;25(6):1060-4. doi: 10.1017/S1047951114001577. Epub 2014 Aug 27.

极早产儿因治疗性扑热息痛剂量导致的急性肝衰竭。

Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate.

机构信息

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand

Neonatal Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand.

出版信息

BMJ Case Rep. 2022 May 6;15(5):e245406. doi: 10.1136/bcr-2021-245406.

DOI:10.1136/bcr-2021-245406
PMID:35523509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9083392/
Abstract

We report the first case of standard therapeutic dose paracetamol for patent ductus arteriosus closure causing acute liver failure in an extremely preterm infant. After 5 days of treatment, he presented with jaundice, acute severe hepatitis and coagulopathy. Treatment with N-acetyl cysteine resulted in full recovery.

摘要

我们报告了首例因标准治疗剂量对乙酰氨基酚治疗动脉导管未闭导致极早产儿急性肝功能衰竭的病例。治疗 5 天后，患儿出现黄疸、急性重症肝炎和凝血功能障碍。给予 N-乙酰半胱氨酸治疗后完全恢复。