Seow Dominique Y B, Tay Timothy K Y, Tan Puay Hoon
Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore.
Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore.
Semin Diagn Pathol. 2022 Sep;39(5):333-343. doi: 10.1053/j.semdp.2022.04.001. Epub 2022 Apr 19.
Breast fibroepithelial lesions, which are composed of biphasic epithelial and stromal proliferations, comprise the fascinating spectrum of fibroadenomas and phyllodes tumours. Common difficulties surrounding their diagnosis include distinguishing between cellular fibroadenomas and benign phyllodes tumours, grading phyllodes tumours, classifying fibroepithelial lesions in paediatric patients, and handling surgical margins. Recent molecular advances have provided insights into the pathogenesis of fibroepithelial lesions and may offer diagnostic, prognostic, and therapeutic information. In this review, we briefly revisit the pathological features of fibroadenomas and phyllodes tumours, discuss common diagnostic dilemmas and management implications, and examine their key molecular characteristics.
乳腺纤维上皮性病变由上皮和间质的双相增生组成，包括纤维腺瘤和叶状肿瘤这一引人关注的谱系。围绕其诊断的常见难题包括区分细胞性纤维腺瘤和良性叶状肿瘤、叶状肿瘤的分级、儿科患者纤维上皮性病变的分类以及手术切缘的处理。最近的分子进展为纤维上皮性病变的发病机制提供了见解，并可能提供诊断、预后和治疗信息。在本综述中，我们简要回顾纤维腺瘤和叶状肿瘤的病理特征，讨论常见的诊断困境和管理意义，并研究它们的关键分子特征。
