Cărăuleanu Alexandru, David Cristina, Mogoş Simona Juliette, Costăchescu Gabriel, Solomon-Condriuc Iustina Petra, Cucu Andrei Ionuţ, Tănase Gabriel Valentin, Costea Claudia Florida, Socolov Demetra Gabriela, Scripcariu Dragoş Viorel, Petrariu Florin Dumitru, Tănase Adina Elena, Tănase Daniela Maria
Department of Ophthalmology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania; 2nd Ophthalmology Clinic, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania;
Rom J Morphol Embryol. 2025 Jan-Mar;66(1):131-136. doi: 10.47162/RJME.66.1.12.
Phyllodes tumors (PTs) of the breast are rare fibroepithelial tumors (FETs), accounting for approximately 0.5% of all breast tumors. The diagnostic interpretation of borderline fibroepithelial lesions often requires further investigations.
PATIENTS, MATERIALS AND METHODS: We used statistical analysis to evaluate the different surgical approaches, risk factors and prognosis during a five-year period, from January 2019 to December 2024, of women who underwent conservative surgeries for benign, borderline tumors and malignant breast tumors.
We examined a total of 481 breast tumors, with benign, borderline and reserved final diagnosis to paraffin, and discovered 35 FETs, corresponding to phyllodes-type tumors. Studies of enlarged PTs, which are often malignant on final paraffin results, are controversial regarding further postoperative treatment, because they require chemotherapy that is as aggressive as for soft tissue sarcomas, and also hormone therapy that has not shown long-term survival benefit yet. In order to improve the quality of life, survival rate, and disease management, the surgical team needs to be up to date with the latest protocols of management of the disease.
Management of breast tumors includes ultrasound examination, digital or three-dimensional (3D) mammography and magnetic resonance imaging (MRI) evaluation, while surgical management is consistent with core needle biopsy procedures and surgical excision known as tumorectomy, followed in certain cases by an enlarged sectorectomy.
Aggressive surgery is sometimes necessary to achieve oncological safety margins and prevent subsequent disease recurrence.
乳腺叶状肿瘤（PTs）是罕见的纤维上皮性肿瘤（FETs），约占所有乳腺肿瘤的0.5%。交界性纤维上皮性病变的诊断解读通常需要进一步检查。
患者、材料与方法：我们采用统计分析方法，评估了2019年1月至2024年12月这五年间接受良性、交界性肿瘤及恶性乳腺肿瘤保守手术的女性的不同手术方式、危险因素及预后情况。
我们共检查了481例乳腺肿瘤，对其进行良性、交界性诊断并保留最终石蜡诊断结果，发现35例FETs，即叶状型肿瘤。对于最终石蜡结果显示常为恶性的巨大PTs，术后进一步治疗存在争议，因为它们需要像软组织肉瘤那样积极的化疗，同时还需要激素治疗，而激素治疗尚未显示出长期生存获益。为了提高生活质量、生存率及疾病管理水平，手术团队需要紧跟该疾病最新的管理方案。
乳腺肿瘤的管理包括超声检查、数字或三维（3D）乳腺钼靶检查及磁共振成像（MRI）评估，而手术管理与粗针活检程序及称为肿瘤切除术的手术切除一致，某些情况下随后进行扩大的区段切除术。
有时需要进行积极的手术以获得肿瘤学安全切缘并预防疾病复发。
