Bailey C J, Brown D, Smith W, Bone A J
Diabetes Res. 1987 Jan;4(1):15-8.
Xiaoke tea is consumed as a traditional herbal treatment for diabetes mellitus in China. An aqueous extract of Xiaoke (1 g of dried plant preparation in 64 ml of water), supplied ad lib in place of drinking water during the induction and development of streptozotocin diabetes in mice, reduced (about 30%) plasma glucose concentrations by 25 days. The polydipsia and hyperphagia of the streptozotocin diabetic mice were also reduced by Xiaoke, and the effects lapsed after treatment was withdrawn. Xiaoke did not significantly alter plasma insulin concentrations. Consumption of the Xiaoke extract by insulin-treated diabetic BB/E Wistar rats did not affect glycaemic control or body wt. When insulin treatment was reduced and discontinued, Xiaoke failed to prevent the progression of severe hyperglycaemia and weight loss. The results suggest that the slowly generated antihyperglycaemic effect of Xiaoke in streptozotocin diabetic mice may involve an extrapancreatic effect on food intake, glucose production or glucose clearance. However, as evidenced in BB/E rats, Xiaoke does not substitute for insulin in the absence of endogenous insulin secretion.
消渴茶在中国作为糖尿病的一种传统草药疗法使用。在小鼠链脲佐菌素糖尿病的诱导和发展过程中，用消渴水提取物（1克干燥植物制剂溶于64毫升水中）随意替代饮用水供应，25天时可使血浆葡萄糖浓度降低（约30%）25%。消渴也降低了链脲佐菌素糖尿病小鼠的多饮和多食，治疗停止后效果消失。消渴未显著改变血浆胰岛素浓度。胰岛素治疗的糖尿病BB/E Wistar大鼠饮用消渴提取物不影响血糖控制或体重。当胰岛素治疗减少并停止时，消渴未能阻止严重高血糖和体重减轻的进展。结果表明，消渴在链脲佐菌素糖尿病小鼠中缓慢产生的降血糖作用可能涉及对食物摄入、葡萄糖生成或葡萄糖清除的胰腺外作用。然而，如在BB/E大鼠中所证明的，在缺乏内源性胰岛素分泌的情况下，消渴不能替代胰岛素。
