Day C, Cartwright T, Provost J, Bailey C J
Department of Pharmaceutical Sciences, Aston University, Birmingham, U.K.
Planta Med. 1990 Oct;56(5):426-9. doi: 10.1055/s-2006-961003.
The hypoglycaemic effect of orally administered extracts of fruits of cultivated Momordica charantia (karela) was examined in normal and streptozotocin diabetic mice. In normal mice, an aqueous extract (A) lowered the glycaemic response to both oral and intraperitoneal glucose, without altering the insulin response. This aqueous extract (A) and the residue after alkaline chloroform extraction (B) reduced the hyperglycaemia in diabetic mice at 1 hour. Material recovered by acid water wash of the chloroform extract remaining after an alkaline water wash (D) produced a more slowly generated hypoglycaemic effect. The results suggest that orally administered karela extracts lower glucose concentrations independently of intestinal glucose absorption and involve an extrapancreatic effect. Two types of hypoglycaemic substances with different time dependent effects are indicated.
研究了口服栽培苦瓜（苦瓜）果实提取物对正常小鼠和链脲佐菌素诱导的糖尿病小鼠的降血糖作用。在正常小鼠中，水提取物（A）降低了口服和腹腔注射葡萄糖后的血糖反应，而不改变胰岛素反应。这种水提取物（A）和碱性氯仿萃取后的残留物（B）在1小时时降低了糖尿病小鼠的高血糖水平。碱性水洗后氯仿提取物经酸性水洗回收的物质（D）产生的降血糖作用起效较慢。结果表明，口服苦瓜提取物可独立于肠道葡萄糖吸收降低血糖浓度，并涉及胰腺外效应。表明存在两种具有不同时间依赖性效应的降血糖物质。
