Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan.
Department of Biochemistry and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Nat Commun. 2022 May 6;13(1):2518. doi: 10.1038/s41467-022-30165-2.
The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABA receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.
神经系统和内分泌系统相互协调，密切影响动物的生理和行为反应。在这里，我们发现 WAKE（编码物为 wide awake，也称为 wake）调节成年雄性黑腹果蝇胰岛素分泌细胞中 GABA 受体对狄氏剂（Rdl）的膜水平。这导致胰岛素样肽的分泌发生变化，这与前胸腺中保幼激素生物合成的变化有关，而前胸腺的变化又导致 20-羟基蜕皮酮水平降低。蜕皮激素信号的减少会改变神经结构，并降低气味受体 67d 嗅觉神经元对雄性特有的性信息素 11-顺式-金合欢烯乙酸酯的感知。这些发现解释了为什么果蝇中缺乏 WAKE 会引起显著的雄性间求偶行为。
