Vencill Jennifer A, Kirsch Janae L, McPherson Keagan, Sprankle Eric, Patten Christi A, Campana Kristie, Brockman Tabetha, Bronars Carrie, Hughes Christine, Gastineau Dennis, Ehlers Shawna L
Department of Psychiatry & Psychology, Mayo Clinic, 200, 1st Street SW, Rochester, MN, 55905, USA.
Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
J Clin Psychol Med Settings. 2025 Mar;32(1):137-144. doi: 10.1007/s10880-024-10013-9. Epub 2024 Apr 14.
Sexual health concerns are one of the most common late effects facing hematopoietic stem cell transplant (HSCT) survivors. The current study tested whether self-reported depression and anxiety symptoms before transplant were associated with embedded items assessing two specific areas of sexual health-sexual interest and sexual satisfaction-one year post-HSCT. Of the 158 study participants, 41% were diagnosed with a plasma cell disorder (n = 60) and most received autologous transplantation (n = 128; 81%). At post-HSCT, 21% of participants reported they were not at all satisfied with their sex life, and 22% were not at all interested in sex. Greater pre-HSCT depressive symptomology was significantly predictive of lower sexual interest (β = -.27, p < .001) and satisfaction (β = -.39, p < .001) at post-HSCT. Similarly, greater pre-HSCT trait anxiety was significantly predictive of lower sexual interest (β = -.19, p = .02) whereas higher levels of state and trait anxiety were both predictive of lower satisfaction (β = -.22, p = .02 and β = -.29, p = .001, respectively). Participant sex significantly moderated the relationship between state anxiety and sexual satisfaction (b = -.05, t = -2.03, p = .04). Additional research examining the factors that contribute to sexual health post-HCST is needed to inform and implement clinical interventions to address these commonly overlooked survivorship concerns.
性健康问题是造血干细胞移植（HSCT）幸存者面临的最常见的晚期影响之一。本研究测试了移植前自我报告的抑郁和焦虑症状是否与评估HSCT后一年性健康两个特定领域——性兴趣和性满意度的嵌入式项目相关。在158名研究参与者中，41%被诊断患有浆细胞疾病（n = 60），大多数接受了自体移植（n = 128；81%）。在HSCT后，21%的参与者报告他们对性生活一点也不满意，22%的人对性生活完全没有兴趣。HSCT前更严重的抑郁症状显著预测了HSCT后较低的性兴趣（β = -0.27，p < 0.001）和满意度（β = -0.39，p < 0.001）。同样，HSCT前更高的特质焦虑显著预测了较低的性兴趣（β = -0.19，p = 0.02），而更高水平的状态焦虑和特质焦虑都预测了较低的满意度（β分别为-0.22，p = 0.02和β = -0.29，p = 0.001）。参与者的性别显著调节了状态焦虑与性满意度之间的关系（b = -0.05，t = -2.03，p = 0.04）。需要进行更多研究来考察导致HSCT后性健康问题的因素，以便为解决这些普遍被忽视的生存问题提供信息并实施临床干预措施。
