Firth E C, Wensing T, Seuren F
Cornell Vet. 1987 Apr;77(2):107-18.
The effects of intra-articular injection of small amounts of E. coli lipopolysaccharide (LPS) into the intercarpal joint of 5 ponies were studied. The LPS induced predictable changes all of which were analogous to acute bacterial infection, except that the development of signs occurred sooner after the LPS injection, and subsided within 36 hours. Fever was monophasic and peaked at 5-7 hours. The ponies exhibited depression, reduced or absent appetite, increased pulse and respiration rates, and lameness. The lameness became evident between 1 and 2 hours after injection, at which time warmth, articular effusion, and resentment to palpation of joint flexion were evident. Hematological changes included neutrophilic leucocytosis, and changes in copper, iron and zinc serum concentrations. The synovial fluid total protein, leucocyte, and alkaline phosphatase levels increased within 2 hours. The mucin precipitation, total protein and leucocyte counts in synovial fluid remained elevated long after clinical and hematological changes had subsided. The model is useful for the study of some aspects of infectious joint disease.
研究了向5匹小马腕关节内注射少量大肠杆菌脂多糖（LPS）的效果。LPS引发了可预测的变化，所有这些变化都类似于急性细菌感染，只是注射LPS后症状出现得更快，并在36小时内消退。发热呈单相，在5 - 7小时达到峰值。小马表现出抑郁、食欲减退或消失、脉搏和呼吸频率增加以及跛行。跛行在注射后1至2小时变得明显，此时关节发热、积液，屈曲关节触诊时疼痛明显。血液学变化包括中性粒细胞增多，以及血清铜、铁和锌浓度的变化。滑液总蛋白、白细胞和碱性磷酸酶水平在2小时内升高。临床和血液学变化消退后很长时间，滑液中的粘蛋白沉淀、总蛋白和白细胞计数仍居高不下。该模型对于研究感染性关节疾病的某些方面很有用。
