Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.
Exp Dermatol. 2022 Jul;31(7):986-992. doi: 10.1111/exd.14600. Epub 2022 May 16.
Due to a steady increase in the number of individuals suffering from alopecia, this condition has recently received increasing attention. Alopecia can be caused by various pathological, environmental or psychological factors, eventually resulting in abnormalities in hair follicle (HF) structures or HF regeneration disorders, especially dysregulated hair follicle stem cell (HFSC) behaviour. HFSC behaviour includes activation, proliferation and differentiation. Appropriate HFSC behaviour sustains a persistent hair cycle (HC). HFSC behaviour is mainly influenced by HFSC metabolism, ageing and the microenvironment. In this review, we summarize recent findings on how HFSC metabolism, ageing and the microenvironment give rise to hair growth disorders, as well as related genes and signalling pathways. Recent research on the application of stem cell-based hair tissue engineering and regenerative medicine to treat alopecia is also summarized. Determining how dysregulated HFSC behaviour underlies alopecia would be helpful in identifying potential therapeutic targets.
由于脱发患者数量的稳步增加，这种情况最近受到了越来越多的关注。脱发可能由各种病理、环境或心理因素引起，最终导致毛囊 (HF) 结构异常或 HF 再生障碍，特别是毛囊干细胞 (HFSC) 行为失调。HFSC 行为包括激活、增殖和分化。适当的 HFSC 行为维持持续的毛发生长周期 (HC)。HFSC 行为主要受 HFSC 代谢、衰老和微环境的影响。在这篇综述中，我们总结了最近关于 HFSC 代谢、衰老和微环境如何导致毛发生长障碍的发现，以及相关的基因和信号通路。还总结了基于干细胞的毛发组织工程和再生医学在治疗脱发方面的最新应用研究。确定失调的 HFSC 行为在脱发中的基础作用将有助于确定潜在的治疗靶点。
