Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, India.
Department of Pharmaceutical Technology, Calcutta Institute of Pharmaceutical Technology and Allied Science, Uluberia, India.
Curr Pharm Biotechnol. 2023;24(8):988-1017. doi: 10.2174/1389201023666220507003726.
The advent and spread of novel coronavirus (nCoV) has posed a new public health crisis since December 2019. Several cases of unexplained pneumonia occurred in Wuhan, Hubei Province, China, only a month before the Chinese Spring festival. After the diagnosis of bronchoalveolar fluid samples of people infected, the new coronavirus was identified using nextgeneration sequence technology. This work aims to provide information regarding COVID-19 that will help the researchers to identify the vital therapeutic targets for SARS-CoV-2 and also will provide insights into some significant findings of recent times highlighted by scientific communities around the globe. In this review, we have tried to explore multiple aspects related to COVID-19, including epidemiology, etiology, COVID-19 variants, vaccine candidates, potential therapeutic targets, the role of natural products, and computational studies in drug design and development, repurposing, and analysis of crystal structures available for COVID-19 related protein structures. Druggable targets include all viral enzymes and proteins involved in viral replication and regulation of host cellular machines. The medical community tracks several therapies to combat the infection by investigating various antiviral and immunomodulatory mechanisms. While some vaccines are approved in this worldwide health crisis, a more precise therapy or drug is formally recommended to be used against SARS-CoV-2 infection. Natural products other than synthetic drugs have been tested by in silico analysis against COVID-19. However, important issues still need to be addressed regarding in vivo bioavailability and better efficacy.
自 2019 年 12 月以来，新型冠状病毒（nCoV）的出现和传播带来了新的公共卫生危机。在中国春节前一个月，湖北省武汉市仅出现了几例不明原因的肺炎病例。在对感染人的肺泡灌洗液样本进行诊断后，使用下一代测序技术鉴定出了新型冠状病毒。这项工作旨在提供有关 COVID-19 的信息，帮助研究人员识别针对 SARS-CoV-2 的重要治疗靶点，并深入了解全球科学界近期强调的一些重要发现。在这篇综述中，我们试图探讨与 COVID-19 相关的多个方面，包括流行病学、病因学、COVID-19 变体、疫苗候选物、潜在的治疗靶点、天然产物的作用以及计算研究在药物设计和开发、重新利用和分析 COVID-19 相关蛋白结构方面的作用。可成药靶点包括参与病毒复制和调节宿主细胞机器的所有病毒酶和蛋白。医学界通过研究各种抗病毒和免疫调节机制，跟踪了几种治疗感染的方法。虽然在这场全球卫生危机中批准了一些疫苗，但正式推荐使用更精确的疗法或药物来对抗 SARS-CoV-2 感染。除了合成药物外，天然产物也已通过针对 COVID-19 的计算机分析进行了测试。然而，关于体内生物利用度和更好的疗效仍有重要问题需要解决。
