Academician Abdulla Garayev Institute of Physiology, NAS, Baku, Azerbaijan.
Institute of Radiation Problems, NAS, Baku, Azerbaijan.
Ecotoxicology. 2022 Jul;31(5):846-851. doi: 10.1007/s10646-022-02540-8. Epub 2022 May 7.
High levels of background γ-radiation exist in the suburbs of Baku, Azerbaijan. We examined the impact of radiation on erythrocyte nuclear pathologies, levels of cytochrome P-450, and serotonin-modulating anticonsolidation protein (SMAP) in the tissues of the hens from three settlements with different levels of background radiation. Higher levels of radiation resulted in increased nuclear pathologies, upregulation of tissue SMAP levels, and downregulation of cytochrome P-450. We also carried out controlled dosage studies on Wistar male rats, which showed significant upregulation of heat shock proteins with molecular mass 70 kDa (HSP70) in the bone marrow 3 and 5 h after SMAP intraperitoneal administration. Administration of SMAP to rats 3 h prior to γ-radiation exposure (8 Gy) provided significant protection to somatic cell nuclei. We conclude that SMAP can provide protection from the genotoxic effects of γ-radiation through upregulation of HSP70 or the transformation of chromatin into a condensed, more protective conformational state.
阿塞拜疆巴库郊区存在高水平的背景γ辐射。我们研究了辐射对来自三个具有不同背景辐射水平的定居点的母鸡组织中红细胞核病理学、细胞色素 P-450 水平和 5-羟色胺调节抗粘连蛋白 (SMAP) 的影响。更高的辐射水平导致核病理学增加、组织 SMAP 水平上调和细胞色素 P-450 下调。我们还对 Wistar 雄性大鼠进行了对照剂量研究，结果显示，SMAP 腹腔给药后 3 和 5 小时，骨髓中分子量为 70 kDa 的热休克蛋白 (HSP70) 显著上调。在 γ 辐射暴露（8 Gy）前 3 小时给予 SMAP 可显著保护体细胞核。我们得出结论，SMAP 通过上调 HSP70 或将染色质转化为浓缩、更具保护作用的构象状态，可提供对 γ 辐射遗传毒性的保护。
