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二氢嘧啶酶相关蛋白2对大鼠记忆形成的影响及其在神经元反向重塑中的可能作用。

Impact of dihydropyrimidinase-related protein 2 in memory formation on rats and its possible role in neuronal back remodeling.

作者信息

Mekhtiev Arif A, Asadova Shamsiyya M

机构信息

Academician Abdulla Garayev Institute of Physiology, Ministry of Science and Education, Baku, Azerbaijan.

出版信息

IBRO Neurosci Rep. 2024 Jan 18;16:155-161. doi: 10.1016/j.ibneur.2024.01.001. eCollection 2024 Jun.

DOI:10.1016/j.ibneur.2024.01.001
PMID:38304064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10831146/
Abstract

The article concerns the problem of molecular mechanisms of memory formation. In this study the effects of polyclonal antibodies to serotonin-modulating anticonsolidation protein (SMAP) complex and its component dihydropyrimidinase-related protein 2 (DRP2) have been analyzed. Intra-cerebral administration of polyclonal anti-SMAP antibody significantly enhanced elaboration and strengthened memory formation in two complex behavioral conditioned models. At the same time, intra-cerebral administration of anti-SMAP antibody resulted in an increase of the content of nerve growth factor (NGF) in the water-soluble fraction of the hippocampus while intra-cerebral administration of anti-DRP2 antibody caused a decrease in the content of β-III tubulin (a marker of differentiated neurons) in the hippocampus and in the left parietal cortex of untrained rats. The obtained results indicate that DRP2 might participate in regulation of the processes of back remodeling of mature nerve cells of adult organisms, occurring during training of rats in the behavioral paradigm used in this study under the effects of anti-SMAP and anti-DRP2 antibodies. Conclusion is made that back remodeling (dedifferentiation) of mature nerve cells, apparently, is engaged in memory formation.

摘要

本文关注记忆形成的分子机制问题。在本研究中，分析了针对血清素调节抗巩固蛋白（SMAP）复合物及其组分二氢嘧啶酶相关蛋白2（DRP2）的多克隆抗体的作用。在两种复杂行为条件模型中，脑内注射多克隆抗SMAP抗体显著增强了记忆的精细加工并强化了记忆形成。同时，脑内注射抗SMAP抗体导致海马水溶性部分神经生长因子（NGF）含量增加，而脑内注射抗DRP2抗体则使未训练大鼠海马和左侧顶叶皮质中β-III微管蛋白（分化神经元的标志物）含量降低。所得结果表明，在本研究使用的行为范式训练大鼠过程中，在抗SMAP和抗DRP2抗体作用下，DRP2可能参与成年生物体成熟神经细胞反向重塑过程的调节。得出的结论是，成熟神经细胞的反向重塑（去分化）显然参与了记忆形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/5542c3ab4957/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/f008b62d65ff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/4f6b46af5c83/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/d4207482ec2e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/57f8b9d12bed/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/97dca41b2cfe/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/5542c3ab4957/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/f008b62d65ff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/4f6b46af5c83/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/d4207482ec2e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/57f8b9d12bed/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/97dca41b2cfe/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b82/10831146/5542c3ab4957/gr6.jpg

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