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2019 冠状病毒病大流行期间呼吸道合胞病毒免疫力下降。

Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic.

机构信息

British Columbia Children's Hospital Research Institute, Vancouver, Canada.

Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

出版信息

J Infect Dis. 2022 Dec 13;226(12):2064-2068. doi: 10.1093/infdis/jiac192.

DOI:10.1093/infdis/jiac192
PMID:35524952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9129162/
Abstract

Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year of the coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report a reduction in RSV antibody levels and live virus neutralization in sera from women of childbearing age and infants between May to June 2020 and February to June 2021, in British Columbia (BC), Canada. This supports that antibody immunity against RSV is relatively short-lived and that maintaining optimal antibody levels in infants requires repeated maternal viral exposure. Waning immunity may explain the interseasonal resurgence of RSV cases observed in BC and other countries.

摘要

在 2019 冠状病毒病（COVID-19）大流行的第一年，各卫生辖区近乎检测不到呼吸道合胞病毒（RSV）。在同一时期，我们报告了加拿大不列颠哥伦比亚省（BC）2020 年 5 月至 6 月至 2021 年 2 月至 6 月期间育龄妇女和婴儿血清中的 RSV 抗体水平和活病毒中和作用降低。这表明针对 RSV 的抗体免疫相对短暂，要使婴儿保持最佳抗体水平，需要母体反复接触病毒。免疫力下降可能解释了在 BC 和其他国家观察到的 RSV 季节性病例的再次出现。