Reicherz Frederic, Viñeta Paramo Marina, Bone Jeffrey N, Lavoie Alexanne, Li Sirui, Golding Liam, Jassem Agatha, Watts Allison, Abu-Raya Bahaa, Lavoie Pascal M
British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
J Infect Dis. 2025 Jun 2;231(5):e840-e845. doi: 10.1093/infdis/jiaf101.
Longitudinal measurements of respiratory syncytial virus (RSV) immunity over 4 winter seasons reveal that viral neutralization titers, RSV prefusion F protein (pre-F)-specific immunoglobulin M and immunoglobulin G (IgG) levels, and RSV antibody-dependent cellular phagocytosis function gradually returned to prepandemic levels in female healthcare and school workers of childbearing age after 2 winter seasons, following the resurgence of RSV cases in the Vancouver metropolitan region (British Columbia, Canada). In contrast, pre-F IgG avidity profiles remained unchanged. These findings support the notion that repeated viral infections are necessary to maintain high RSV antibody levels in the population.
对4个冬季呼吸道合胞病毒（RSV）免疫力的纵向测量结果显示，在加拿大不列颠哥伦比亚省温哥华都会区RSV病例再度出现后，育龄女性医护人员和学校工作人员在经历两个冬季后，病毒中和滴度、RSV融合前F蛋白（pre-F）特异性免疫球蛋白M和免疫球蛋白G（IgG）水平以及RSV抗体依赖性细胞吞噬功能逐渐恢复到疫情前水平。相比之下，pre-F IgG亲和力谱保持不变。这些发现支持了这样一种观点，即反复的病毒感染对于维持人群中较高的RSV抗体水平是必要的。
