Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA.
Capital Veterinary Specialists, Jacksonville, FL.
Am J Vet Res. 2022 May 8;83(6):ajvr.21.11.0189. doi: 10.2460/ajvr.21.11.0189.
To evaluate cardiac output (CO) measurements using transpulmonary ultrasound (TPUD) technology and compare results with those of the gold standard, pulmonary arterial catheter thermodilution (PACTD), in 6 healthy anesthetized pigs during acute hemodynamic changes caused by manipulation of the blood volume.
6 healthy male Landrace pigs.
Over a period of 1 week, pigs were anesthetized with isoflurane, mechanically ventilated, and underwent instrumentation in dorsal recumbency. They were subjected to sequential experimental states during which the blood volume was manipulated so that the animals transitioned from normovolemia to hypovolemia (20% and 40% of blood volume depletion), back to normovolemia (autologous blood transfusion), and then to hypervolemia (following colloid bolus). During each volume state, CO measurements were compared between TPUD and PACTD.
The mean ± SD relative bias between TPUD and PACTD was 7.71% ± 21.2% with limits of agreement -33.9% to 49.3%, indicating TPUD slightly underestimated CO values, compared with values obtained with PACTD. The mean ± SD of the bias between the 2 methods was 0.13 ± 0.5 L/min. Only 5 of 36 (13.9%) TPUD CO measurements had an absolute value of relative bias > 30%. The percentage error calculated for TPUD was 29.4%.
Results suggested that TPUD measurements have acceptable agreement with PACTD measurements. Moreover, TPUD exhibits promising potential in being used interchangeably with PACTD for future hemodynamic research involving swine as species of interest.
评估经肺超声（TPUD）技术测量心输出量（CO）的效果，并在 6 头麻醉健康猪因血容量变化引起急性血流动力学变化期间，将结果与肺动脉导管热稀释（PACTD）的金标准进行比较。
6 头健康雄性长白猪。
在 1 周的时间内，猪通过异氟烷麻醉、机械通气并在仰卧位接受仪器操作。它们经历了一系列实验状态，在这些状态下，血容量被操纵，使动物从正常血容量过渡到低血容量（血容量减少 20%和 40%），再回到正常血容量（自体输血），然后再过渡到高血容量（胶体液推注后）。在每个容量状态下，比较了 TPUD 和 PACTD 之间的 CO 测量值。
TPUD 与 PACTD 之间的平均±SD 相对偏差为 7.71%±21.2%，一致性界限为-33.9%至 49.3%，表明与 PACTD 相比，TPUD 略低估了 CO 值。两种方法之间的平均±SD 偏差为 0.13±0.5 L/min。只有 36 次 TPUD CO 测量中的 5 次（13.9%）的绝对相对偏差值>30%。TPUD 的计算百分比误差为 29.4%。
结果表明，TPUD 测量与 PACTD 测量具有良好的一致性。此外，TPUD 在作为研究物种的猪的未来血流动力学研究中具有与 PACTD 互换使用的潜在前景。
