College of Life Sciences, Tonghua Normal University, Tonghua 134002, China.
College of Life Sciences, Tonghua Normal University, Tonghua 134002, China.
Comp Biochem Physiol C Toxicol Pharmacol. 2022 Aug;258:109362. doi: 10.1016/j.cbpc.2022.109362. Epub 2022 May 5.
The heavy metal cadmium (Cd) is a kind of non-essential toxic environmental pollutant with extremely long biological half-life, various toxic and sublethal effects on aquatic organisms, and many adverse effects on the organs of human and other mammals. Vitamin C is an essential micronutrient in aquatic feed, and an indispensable nutrient for maintaining physiological processes in different animals, including fish. The aim of this study was to evaluate the effects of administration of Vitamin C on bioaccumulation, hematological parameters and heat shock protein-related genes of common carp following Cd exposure. The fish were exposed to waterborne Cd at 0, 1 and 2 mg/L and administration Vitamin C at 150 and 300 mg/kg for 8 weeks. The results obtained indicate that Vitamin C can provide a significant protective effect on the toxicity of cadmium by inhibiting alterations in the levels of bioaccumulation, hematological parameters (including calcium, magnesium, glucose, alkaline phosphatase (ALP), glutamic-pyruvic transaminase (ALT), aspartate transaminase (AST), total protein, lactate dehydrogenase (LDH), cholesterol and lysozyme (LZM)) and heat shock protein-related genes (Hsp70, Hsp90, Hsp47 and Hsp60). Our study demonstrates that vitamin C has the potential to reduce heavy metal damage to common carp and improve immunity.
重金属镉 (Cd) 是一种非必需的有毒环境污染物，具有极长的生物半衰期、对水生生物的多种毒性和亚致死效应，以及对人类和其他哺乳动物器官的许多不良影响。维生素 C 是水产饲料中的必需微量营养素，也是包括鱼类在内的不同动物维持生理过程所必需的营养物质。本研究旨在评估维生素 C 给药对暴露于 Cd 后的鲤鱼生物积累、血液学参数和热休克蛋白相关基因的影响。鱼在 0、1 和 2mg/L 的水中暴露于 Cd 并接受 150 和 300mg/kg 的维生素 C 治疗 8 周。结果表明，维生素 C 通过抑制生物积累水平、血液学参数（包括钙、镁、葡萄糖、碱性磷酸酶（ALP）、谷氨酸-丙酮酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总蛋白、乳酸脱氢酶（LDH）、胆固醇和溶菌酶（LZM））和热休克蛋白相关基因（Hsp70、Hsp90、Hsp47 和 Hsp60）的变化，对镉的毒性提供了显著的保护作用。我们的研究表明，维生素 C 有可能减轻重金属对鲤鱼的损害并提高免疫力。
