Hall C E, Hungerford S
Can J Physiol Pharmacol. 1984 Apr;62(4):436-40. doi: 10.1139/y84-069.
Weekly subcutaneous implantation of 25-mg nitrendipine pellets prevented onset of both spontaneous and deoxycorticosterone-salt hypertension in rats. Discontinuance of implantation led to reappearance of hypertension after about 2 weeks in the former and led to rising though still normotensive pressures after about 3 weeks in the latter. A new implant caused blood pressures in both to drop within a day or two to normotensive levels in the case of spontaneously hypertensive rats. Nitrendipine prevented cardiac hypertrophy in steroid hypertensive rats, but not in spontaneous hypertensives. A nitrendipine pellet given 1 day before or a 30 mg/kg injection given 1 h prior to the administration of a water, Na+, and K+ load, prevented the diabetes insipidus-like syndrome resulting from deoxycorticosterone-salt treatment, and lowered sodium but not potassium excretion. Nitrendipine did not affect steroid-induced hypernatremia and hypokalemia.
每周皮下植入25毫克尼群地平微丸可预防大鼠自发性高血压和脱氧皮质酮-盐性高血压的发生。停止植入后，前者约2周后高血压复发，后者约3周后血压虽仍处于正常血压水平但开始上升。对于自发性高血压大鼠，新植入微丸可使血压在一两天内降至正常血压水平。尼群地平可预防类固醇性高血压大鼠的心脏肥大，但对自发性高血压大鼠无效。在给予水、钠和钾负荷前1天给予尼群地平微丸或提前1小时给予30毫克/千克注射，可预防脱氧皮质酮-盐治疗导致的尿崩症样综合征，并降低钠排泄但不影响钾排泄。尼群地平不影响类固醇诱导的高钠血症和低钾血症。
