Qin Yongwei, Chen Yujie, Chen Jinliang, Xu Kuang, Xu Feifan, Shi Jiahai
Department of Pathogen Biology, Medical College, Nantong University, No. 19 Qixiu Road, Nantong, China.
Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Nantong Clinical Medical Research Center of Cardiothoracic Disease, and Institution of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China.
Infect Agent Cancer. 2022 May 7;17(1):20. doi: 10.1186/s13027-022-00434-2.
Various investigations have expanded the views that tuberculosis is an important risk factor for lung cancer occurrence. Lung cancer originates from chronic inflammation and infection. It is becoming clearer that Mycobacterium tuberculosis (M.tb) in tuberculosis patients meticulously schemes multiple mechanisms to induce tumor formation and is indispensable to participate in the occurrence of lung cancer. In addition, some additional factors such as age, sex and smoking, accelerate the development of lung cancer after Mycobacterium tuberculosis infection. The clarification of these insights is fostering new diagnoses and therapeutic approaches to prevention of the patients developing from tuberculosis into lung cancer.
多项研究拓展了关于结核病是肺癌发生重要危险因素的观点。肺癌起源于慢性炎症和感染。越来越清楚的是，结核病患者体内的结核分枝杆菌精心策划多种机制诱导肿瘤形成，并且在肺癌发生过程中不可或缺。此外，年龄、性别和吸烟等一些其他因素，在结核分枝杆菌感染后加速肺癌的发展。对这些见解的阐明正在催生预防患者从结核病发展为肺癌的新诊断和治疗方法。
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