多糖的化学合成。
Chemical synthesis of polysaccharides.
机构信息
Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
出版信息
Curr Opin Chem Biol. 2022 Aug;69:102154. doi: 10.1016/j.cbpa.2022.102154. Epub 2022 May 5.
Here we summarize the chemical syntheses of glycans containing over 20 monosaccharide units, with the recent syntheses of ultra-long glycans, including a 92mer arabinogalactan, a 100mer and a 151mer mannan, and a 128mer rhamnomannan, being highlighted. The assembly strategies, glycosylation methods, and protecting group manipulations, which are crucial to the successful synthesis, are discussed to give guidance for the future synthesis of various polysaccharides.
在这里，我们总结了含有 20 个以上单糖单元的聚糖的化学合成方法，重点介绍了最近超多糖的合成，包括一个 92 mer 的阿拉伯半乳聚糖、一个 100mer 和一个 151mer 的甘露聚糖，以及一个 128mer 的鼠李半乳糖甘露聚糖。讨论了组装策略、糖基化方法和保护基操作，这些对于成功合成至关重要，为未来各种多糖的合成提供了指导。
Zotero 插件