系统性红斑狼疮中的 T 细胞失调。
T cell dysregulation in SLE.
机构信息
Dept of Pediatrics, Pediatric Rheumatology, RWTH Aachen University, Aachen, Germany.
Dept of Medicine, Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
出版信息
Clin Immunol. 2022 Jun;239:109031. doi: 10.1016/j.clim.2022.109031. Epub 2022 May 6.
T helper cells aid B cells with the production of antibodies and thus play a central role in disease development of systemic lupus erythematosus (SLE). Numerous T helper cell abnormalities have been described in SLE patients that contribute to disease pathophysiology and provide suitable targets for therapeutic intervention. In addition, T effector cell also play a less well-defined role in SLE. This review focusses on underlying molecular mechanisms of different T cell alterations in SLE.
辅助性 T 细胞（T helper cells）有助于 B 细胞产生抗体，因此在系统性红斑狼疮（systemic lupus erythematosus，SLE）的发病机制中发挥核心作用。在 SLE 患者中已经描述了许多辅助性 T 细胞异常，这些异常有助于疾病的病理生理学，并为治疗干预提供了合适的靶点。此外，T 效应细胞在 SLE 中的作用也不那么明确。这篇综述重点介绍了 SLE 中不同 T 细胞改变的潜在分子机制。
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