Dept of Pediatrics, Pediatric Rheumatology, RWTH Aachen University, Aachen, Germany.
Dept of Medicine, Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Clin Immunol. 2022 Jun;239:109031. doi: 10.1016/j.clim.2022.109031. Epub 2022 May 6.
T helper cells aid B cells with the production of antibodies and thus play a central role in disease development of systemic lupus erythematosus (SLE). Numerous T helper cell abnormalities have been described in SLE patients that contribute to disease pathophysiology and provide suitable targets for therapeutic intervention. In addition, T effector cell also play a less well-defined role in SLE. This review focusses on underlying molecular mechanisms of different T cell alterations in SLE.
辅助性 T 细胞（T helper cells）有助于 B 细胞产生抗体，因此在系统性红斑狼疮（systemic lupus erythematosus，SLE）的发病机制中发挥核心作用。在 SLE 患者中已经描述了许多辅助性 T 细胞异常，这些异常有助于疾病的病理生理学，并为治疗干预提供了合适的靶点。此外，T 效应细胞在 SLE 中的作用也不那么明确。这篇综述重点介绍了 SLE 中不同 T 细胞改变的潜在分子机制。
