Allende-Riera A, Hdez-Armas J, Oton-Sanchez C
Eur J Nucl Med. 1987;12(10):482-5. doi: 10.1007/BF00620470.
Using bone scintigraphs (B.S.) from neoplasic patients, a quantitative analysis of the relation existing between objective scintigraphic signs and the diagnosis of presence or absence of bone metastases was carried out. In this way, an attempt was made to increase the specificity of the B.S. for this diagnosis. Thus, a group of signs from the B.S. was chosen and an analysis of the frequency of their presence in relation to the diagnosis of bone metastasis was carried out. For each sign, considered as discrete mathematical variables, an index arising from the following expression: Sensitivity - (1 - Specificity) was calculated. In this manner, each scintigraph may be quantified by the addition of the indices which correspond to the signs present in it. The set of possible numerical values was divided into 7 intervals, each of which establishes a different degree of reliability in the diagnosis of bone metastasis. This approach permitted ROC analysis and the formation of the representative curve.
利用肿瘤患者的骨闪烁扫描图（B.S.），对客观闪烁扫描征象与骨转移存在与否的诊断之间的关系进行了定量分析。通过这种方式，试图提高B.S.对该诊断的特异性。因此，从B.S.中选取了一组征象，并对其出现频率与骨转移诊断的关系进行了分析。对于每个被视为离散数学变量的征象，计算了由以下表达式得出的指数：灵敏度 - （1 - 特异性）。通过这种方式，每个闪烁扫描图可以通过将与其所含征象相对应的指数相加来进行量化。可能的数值集被分为7个区间，每个区间在骨转移诊断中建立了不同程度的可靠性。这种方法允许进行ROC分析并形成代表性曲线。
