Neuman M, Rufin F
Eur Urol. 1987;13 Suppl 1:105-7. doi: 10.1159/000472873.
Oral single-dose therapy with fosfomycin-trometamol (F-T) was used in 18 patients with lower urinary tract infections. The isolated bacterial strains presented a minimum inhibitory concentration of greater than 128 micrograms/ml in vitro. In spite of this 'resistance' in vitro, a clinical and bacteriological cure was obtained in 12 cases (66%). There were relapses in 2 cases, and clinical and bacteriological failure in only 2 cases. These results are due to the high urinary levels and prolonged bactericidal activity of urine after single-dose therapy with 3-5 g F-T. The clinical and biological tolerance was very good.
18例下尿路感染患者采用口服单剂量磷霉素氨丁三醇（F-T）治疗。分离出的菌株在体外的最低抑菌浓度大于128微克/毫升。尽管在体外存在这种“耐药性”，但12例（66%）患者获得了临床和细菌学治愈。2例复发，仅2例出现临床和细菌学治疗失败。这些结果归因于单剂量3-5克F-T治疗后尿液中高浓度和延长的杀菌活性。临床和生物学耐受性非常好。
