Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Institute of Clinical Sciences, University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom; Department of Ophthalmology, Birmingham & Midland Eye Centre, Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom.
Arch Soc Esp Oftalmol (Engl Ed). 2022 May;97(5):264-275. doi: 10.1016/j.oftale.2021.01.012. Epub 2022 Feb 17.
The microbiome is strongly implicated in a wide spectrum of immune-mediated diseases, whereas gut commensal microbiota plays a pivotal role in immune and intestinal homeostasis.
A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items.
Due to complex interactions with the host genetics and other factors, intestinal dysbiosis has been linked to various immune-mediated disorders. In particular, the role of intestinal microbiota in the pathogenesis of uveitis has been demonstrated by several studies, indicating that changes in the microbiome can trigger autoimmune ocular inflammatory processes or affect their severity.
This review summarizes how alterations in the intestinal microbiota can conduce to immune-mediated ocular pathologies and how microbiome can be targeted in order to form novel therapeutic approaches to treat these severe and potentially blinding conditions.
微生物组与广泛的免疫介导性疾病密切相关，而肠道共生微生物群在免疫和肠道稳态中起着关键作用。
在 PubMed 数据库中进行了全面的文献检索。在 Google Scholar 中进行了额外的搜索，以完成收集的项目。
由于与宿主遗传和其他因素的复杂相互作用，肠道菌群失调与各种免疫介导的疾病有关。特别是，肠道微生物群在葡萄膜炎发病机制中的作用已被多项研究证实，表明微生物组的变化可以引发自身免疫性眼部炎症过程或影响其严重程度。
本综述总结了肠道微生物组的改变如何导致免疫介导性眼部病变，以及如何针对微生物组形成新的治疗方法来治疗这些严重且可能致盲的疾病。
