胃肠道微生物群与眼部疾病之间的联系
The Link Between Gastrointestinal Microbiome and Ocular Disorders.
作者信息
Alfuzaie Rashed
机构信息
Ibn Sina Hospital, Shuwaikh, Kuwait.
出版信息
Clin Ophthalmol. 2023 Jul 25;17:2133-2140. doi: 10.2147/OPTH.S415425. eCollection 2023.
Abstract
The gut-eye axis has been hypothesized to be a factor in many eye pathologies. This review examines papers from PubMed about this topic. Bacterial commensals could either be protective by regulating the immune system or prove to be damaging to the gut mucosal wall and incite an inflammatory process. The balance between the two appears to be crucial in maintaining eye health. Imbalances have been implicated in ophthalmologic conditions. The use of probiotics, dietary modifications, antibiotics, and faecal microbiota transplant in mice with pathologies such as those encountered in our practice appears to reverse disease course or at least prevent its progression. Clinical trials are currently underway to investigate their clinical significance in diseased patients.
摘要
肠-眼轴被认为是许多眼部疾病的一个影响因素。本综述研究了来自PubMed上关于该主题的论文。共生细菌可能通过调节免疫系统起到保护作用，也可能对肠道黏膜壁造成损害并引发炎症过程。两者之间的平衡对于维持眼部健康似乎至关重要。失衡与眼科疾病有关。在患有我们临床中遇到的诸如某些病症的小鼠中，使用益生菌、饮食调整、抗生素和粪便微生物群移植似乎可以逆转疾病进程或至少阻止其进展。目前正在进行临床试验以研究它们在患病患者中的临床意义。
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