Moi Meng Ling
Institute of Tropical Medicine, Nagasaki University.
Uirusu. 2021;71(1):1-10. doi: 10.2222/jsv.71.1.
Dengue, an arbovirus, is a public health treat in the tropics and sub-tropical climates worldwide. The disease incidence has grown dramatically worldwide, with an estimated 390 million dengue virus infection per year. Dengue has distinct epidemiological patterns which are associated with the four virus serotypes. All four serotypes can co-circulate within a region, in which a number of regions are hyperendemic for all 4 serotypes. Currently, there are no specific treatment or vaccine for the disease. Dengue prevention depends on vector control measures and early interventions. The COVID-19 pandemic has placed immense pressure on health care and management systems worldwide. During the COVID-19 pandemic, the situation was aggravated by the simultaneous dengue outbreaks, that has led to a double burden which has further impacted the healthcare sector, particularly in resource limited settings. This review article will focus on dengue epidemics during the COVID-19 pandemic and discuss on recent findings on immunological cascades between dengue and COVID-19 and, the impact on vaccine development.
登革热是一种虫媒病毒,在全球热带和亚热带气候地区构成公共卫生威胁。全球范围内该疾病的发病率急剧上升,估计每年有3.9亿人感染登革热病毒。登革热具有与四种病毒血清型相关的独特流行病学模式。所有四种血清型都可在一个地区共同传播,其中一些地区对所有四种血清型均为高度流行区。目前,该疾病尚无特效治疗方法或疫苗。登革热的预防依赖于病媒控制措施和早期干预。新冠疫情给全球医疗保健和管理系统带来了巨大压力。在新冠疫情期间,登革热同时爆发使情况更加恶化,导致了双重负担,进一步影响了医疗保健部门,尤其是在资源有限的地区。这篇综述文章将聚焦新冠疫情期间的登革热流行情况,并讨论登革热与新冠之间免疫级联反应的最新研究结果以及对疫苗研发的影响。